2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. CHI3L1-IN-3

CHI3L1-IN-3 是一种 CHI3L1 抑制剂。CHI3L1-IN-3 与 CHI3L1 结合，MST 和 SPR 测定表明，Kd 值分别为 13.76 μM 和 13.5 μM。CHI3L1-IN-3 展现出较长的血浆半衰期和微粒体稳定性，同时具有较低的内在清除率。CHI3L1-IN-3 在三维多细胞胶质母细胞瘤 (GBM) 球体模型中诱导剂量依赖性细胞毒性，减少球体质量并抑制细胞迁移。CHI3L1-IN-3 可用于胶质母细胞瘤的研究。

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CHI3L1-IN-3

CHI3L1-IN-3 Chemical Structure

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CHI3L1-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHI3L1-IN-3 is a CHI3L1 inhibitor. CHI3L1-IN-3 binds to CHI3L1 with Kds of 13.76 μM and 13.5 μM in MST and SPR assays, respectively. CHI3L1-IN-3 demonstrates extended plasma half-lives and microsomal stability, along with reduced intrinsic clearance. CHI3L1-IN-3 induces dose-dependent cytotoxicity, reduces spheroid mass and inhibits migration in a 3D multicellular glioblastoma (GBM) spheroid model. CHI3L1-IN-3 can be used for the study of GBM[1].

体外研究
(In Vitro)

CHI3L1-IN-3 (Compound 11g) 展现出增强的稳定性，血浆半衰期分别为小鼠 2.0 小时和人 2.5 小时，微粒体半衰期分别为小鼠 2.2 小时和人 2.8 小时，并且表现出较低的清除率，小鼠为 15 mL/min/mg，人为 19 mL/min/mg[1]。
CHI3L1-IN-3 (50 μM, 72 h) 在 hBMECs 和 HepG2 细胞中表现出低细胞毒性，在 NHA 细胞中无细胞毒性[1]。
CHI3L1-IN-3 (5-25 μM, 72 h) 剂量依赖性抑制胶质母细胞瘤 (GBM) 球体细胞活力[1]。
CHI3L1-IN-3 (10 μM, 72 h) 使球体重量减少超过 50%，与广泛的细胞死亡和结构凝聚力丧失一致[1]。
CHI3L1-IN-3 (10 μM, 24-96 h) 抑制 GBM 球体迁移达 60%[1]。
CHI3L1-IN-3 在胶质母细胞瘤细胞系中表现出抗增殖活性，IC50 值分别为 U251 MG 细胞 2.19 μM 和 T98G 细胞 5.06 μM [1]。
CHI3L1-IN-3 (5-25 μM, 72 h) 在胶质母细胞瘤 (GBM) 球体中剂量依赖性方式降低 pSTAT3 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CHI3L1-IN-3 相关抗体:

Cell Viability Assay[1]

Cell Line: GBM spheroids
Concentration: 5, 10, 25 μM
Incubation Time: 72 h
Result: Showed a dose-dependent reduction in cell viability of GBM spheroids.

Cell Migration Assay [1]

Cell Line: GBM spheroids
Concentration: 5, 10, 25 μM
Incubation Time: 24, 48, 72, 96 h
Result: Suppressed GBM spheroids migration by 60 %.
分子量

563.66

Formula

C30H33N3O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CHI3L1-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHI3L1-IN-3GlycosidaseCHI3L1GBM spheroidsU251 MG cellsT98G cellsInhibitorinhibitorinhibit

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