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  3. Chlorhexidine (digluconate)

Chlorhexidine (digluconate)  (Synonyms: 氯己定二葡糖酸盐)

目录号: HY-B0608 纯度: ≥98.0%
COA 产品使用指南

Chlorhexidine digluconate 是一种氯苯基双胍,对革兰氏 (+) 和 (-) 细菌和真菌具有广泛的抗菌作用。Chlorhexidine digluconate 是一种广谱防腐剂和消毒剂。Chlorhexidine digluconate 通过杀死唾液和舌头中的细菌,有效预防和控制口腔传染病。Chlorhexidine digluconate 是一种细胞毒剂,可诱导细胞坏死和凋亡。

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Chlorhexidine (digluconate) Chemical Structure

Chlorhexidine (digluconate) Chemical Structure

CAS No. : 18472-51-0

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规格 价格 是否有货 数量
5 g (222.8 mM * 25 mL in Water) ¥350
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20 g (222.8 mM * 100 mL in Water) ¥550
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Other Forms of Chlorhexidine (digluconate):

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Top Publications Citing Use of Products

    Chlorhexidine (digluconate) purchased from MCE. Usage Cited in: Cancer Res. 2019 Feb 1;79(3):534-545.  [Abstract]

    The half-life of p53 protein is detected in GYS2 overexpressed cells by added with Chlorhexidine (CHX, 20 μg/mL) for different times.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis[1][2][3].

    体外研究
    (In Vitro)

    Chlorhexidine digluconate (0.00001%、0.00005%、0.0001%、0.0005%;1-4 小时) 对 CHO 细胞具有细胞毒性作用。Chlorhexidine digluconate 以剂量依赖性和时间依赖性的方式降低 CHO 细胞脱氢酶的活性[2]
    Chlorhexidine digluconate (0.00005%、0.0001%、0.0005%;1 小时) 分别引起约 1.62%、5.51% 和 5.47% 的细胞凋亡量,细胞坏死量分别为 2.38%、8.62%、22.50%[2]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Cytotoxicity Assay[2]

    Cell Line: Chinese hamster ovary cells
    Concentration: 0.00001%, 0.00005%, 0.0001%, 0.0005%
    Incubation Time: 1, 2, 4 h
    Result: Demonstrated a cytotoxic effect on CHO cells.

    Apoptosis Analysis[2]

    Cell Line: Chinese hamster ovary cells
    Concentration: 0.00005%, 0.0001%, 0.0005%
    Incubation Time: 1 h
    Result: After a 1 hour treatment, the amount of cell apoptosis was about 1.62%, 5.51%, and 5.47%, respectively.
    The amount of cell necrosis was 2.38%, 8.62%, and 22.50%, respectively.
    体内研究
    (In Vivo)

    Chlorhexidine gluconate (0.05%、0.025%;一次性腹腔注射) 与仅用生理盐水灌洗的小鼠相比,0.05% 的浓度可以显着降低灌洗术后腹内脓肿发生率[1]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Imprinting Control Region (ICR) mice at 6 to 8-wk-old (body weight, 25g)[1]
    Dosage: Chlorhexidine gluconate 0.05% and 0.025%
    Administration: One-time intraperitoneal injection
    Result: With 0.05% lavage had significantly lower incidence of postoperative intra-abdominal abscesses compared with the mice that had saline lavage only.
    Clinical Trial
    分子量

    897.76

    Formula

    C34H54Cl2N10O14

    CAS 号
    性状

    液体

    颜色

    Colorless to light yellow

    中文名称

    葡萄糖酸氯己定;葡萄糖酸洗必泰;氯己定二葡糖酸盐;洗必泰葡萄糖酸盐

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Solution, -20°C, 2 years

    溶解性数据
    In Vitro: 

    H2O 中的溶解度 : 100 mg/mL (111.39 mM; 超声助溶)

    DMSO 中的溶解度 : ≥ 38 mg/mL (42.33 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

    * "≥" means soluble, but saturation unknown.

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    In Vivo:

    以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂: PBS

      Solubility: 100 mg/mL (111.39 mM); 澄清溶液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: ≥98.0%

    参考文献

    Chlorhexidine (digluconate) 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 1.1139 mL 5.5694 mL 11.1388 mL 27.8471 mL
    5 mM 0.2228 mL 1.1139 mL 2.2278 mL 5.5694 mL
    10 mM 0.1114 mL 0.5569 mL 1.1139 mL 2.7847 mL
    15 mM 0.0743 mL 0.3713 mL 0.7426 mL 1.8565 mL
    20 mM 0.0557 mL 0.2785 mL 0.5569 mL 1.3924 mL
    25 mM 0.0446 mL 0.2228 mL 0.4456 mL 1.1139 mL
    30 mM 0.0371 mL 0.1856 mL 0.3713 mL 0.9282 mL
    40 mM 0.0278 mL 0.1392 mL 0.2785 mL 0.6962 mL
    H2O 50 mM 0.0223 mL 0.1114 mL 0.2228 mL 0.5569 mL
    60 mM 0.0186 mL 0.0928 mL 0.1856 mL 0.4641 mL
    80 mM 0.0139 mL 0.0696 mL 0.1392 mL 0.3481 mL
    100 mM 0.0111 mL 0.0557 mL 0.1114 mL 0.2785 mL

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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