2. GPCR/G Protein Neuronal Signaling Anti-infection
  3. 5-HT Receptor SARS-CoV
  4. Cinanserin

Cinanserin (SQ 10643) 是一种有效的，选择性的 5-HT2 拮抗剂，其对 5-HT2 和 5-HT1 的 Ki 值分别为 41 和 3500 nM。Cinanserin 还是一种 SARS-CoV 3CLpro 抑制剂，其对 SARS-CoV 3CLpro 和 HCoV-229E 3CLpro 的 KD 值分别为 49.4 和 18.2 µM。Cinanserin 可降低全身烧伤水肿水平。

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Cinanserin Chemical Structure

Cinanserin Chemical Structure

CAS No. : 1166-34-3

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Cinanserin 的其他形式现货产品:

Other Forms of Cinanserin:

Cinanserin 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cinanserin (SQ 10643) is a potent and selective 5-HT2 antagonist with Ki values of 41, 3500 nM for 5-HT2, 5-HT1, respectively. Cinanserin also is a SARS-CoV 3CLpro inhibitor with an KD value of 49.4, 18.2 µM for SARS-CoV 3CLpro, HCoV-229E 3CLpro, respectively. Cinanserin reduces systemic burn edema levels[1][2][3].

IC50 & Target[2][3]

5-HT2 Receptor

41 nM (Ki)

5-HT1 Receptor

3500 nM (Ki)

SARS-CoV 3CLpro

49.4 μM (Kd)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero CC50
31 μM
Compound: 8
Cytotoxicity against african green monkey Vero E6 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against african green monkey Vero E6 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 23231439]
体内研究
(In Vivo)

Cinanserin (5 mg/kg; i.v.) 治疗可显著降低全身烧伤水肿水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (250 g) underwent thermal injury[1]
Dosage: 5 mg/kg
Administration: Intravenous injection; for 2 hours
Result: Significantly reduced systemic burn edema to shamburn levels, leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.
分子量

340.48

Formula

C20H24N2OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cinanserin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cinanserin1166-34-35-HT ReceptorSARS-CoVSerotonin Receptor5-hydroxytryptamine ReceptorSARS coronavirusMRC-5 cellsHCoV-229Eburn edemaInhibitorinhibitorinhibit

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