2. Neuronal Signaling
  3. α-synuclein
  4. Cinpanemab

Cinpanemab  (Synonyms: 辛帕奈单抗; BIIB054; Anti-Alpha-synuclein Reference Antibody (cinpanemab))

目录号: HY-P99356 纯度: ≥99.0%
COA 技术支持

Cinpanemab (BIIB054) 是一种人源单克隆抗体，可与 α-突触核蛋白 1-10 位残基结合。Cinpanemab 可用于研究帕金森病。

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CAS No. : 2094516-02-4

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规格 价格 是否有货 数量
1 mg ￥2500
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5 mg ￥6000
In-stock
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50 mg   询价  

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Cinpanemab 相关抗体

Top Publications Citing Use of Products

查看 α-synuclein 亚型特异性产品:

查看所有亚型
α-synuclein α-synuclein Aggregation α-synuclein/CHMP2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cinpanemab (BIIB054) is a human-derived monoclonal antibody that binds to α-synuclein. Cinpanemab can be used for the research of Parkinson's disease[1][2].

同型

Human IgG1 lambda1
推荐同型对照抗体
种属

Humanized
IC50 & Target

α-synuclein

 

体外研究
(In Vitro)

Cinpanemab 对聚合形式的 α-syn 具有高度选择性，对纤维状重组 α-syn 的表观亲和力至少比单体重组 α-syn 高 800 倍，并且对人 PD 脑组织有强烈的偏好[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cinpanemab 相关抗体:
体内研究
(In Vivo)

Cinpanemab (30 mg/kg; 腹腔注射) 改善 α-syn PFF 接种小鼠模型中的 PD 样表型[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6JRccHsd WT mice, transgenic M83 mice expressing human α-syn A53T, and transgenic bacterial artificial chromosome mice expressing human α-syn A53T were anesthetized and stereotaxically injected with α-syn preformed fibrils (PFFs) into the right forebrain[2]
Dosage: 30 mg/kg
Administration: Intraperitoneal (i.p.) injections 2-3 times prior to α-syn PFF injection and weekly post-injection until time of sacrifice
Result: Attenuated the spreading of α-syn pathology, rescued motor impairments, and reduced the loss of dopamine transporter density in dopaminergic terminals in striatum.
Clinical Trial
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

146.98 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

辛帕奈单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
Biological Activity
  • Immobilized Human SNCA Protein, Human (HY-P70577) can bind Cinpanemab. The EC50 for this effect is 10.13 ng/mL.
纯度 & 产品资料

纯度: ≥99.0%

COA (265 KB) SDS-PAGE (69 KB) SEC-HPLC (133 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Cinpanemab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cinpanemab2094516-02-4BIIB054Anti-Alpha-synuclein Reference Antibody (cinpanemab)辛帕奈单抗BIIB 054BIIB-054α-synucleinα-SynParkinson's diseaseInhibitorinhibitorinhibit

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