2. Neuronal Signaling
  3. α-synuclein
  4. Cinpanemab

Cinpanemab  (Synonyms: BIIB054; Anti-Alpha-synuclein Reference Antibody (cinpanemab))

目录号: HY-P99356 纯度: 95.00%
COA

摩尔计算器

Cinpanemab (BIIB054) 是一种人源单克隆抗体，可与 α-突触核蛋白 1-10 位残基结合。Cinpanemab 可用于研究帕金森病。

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Cinpanemab Chemical Structure

Cinpanemab Chemical Structure

CAS No. : 2094516-02-4

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7800
In-stock
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50 mg   询价  

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Cinpanemab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cinpanemab (BIIB054) is a human-derived monoclonal antibody that binds to α-synuclein. Cinpanemab can be used for the research of Parkinson's disease[1][2].

IC50 & Target

α-synuclein[1]
体外研究
(In Vitro)

Cinpanemab 对聚合形式的 α-syn 具有高度选择性，对纤维状重组 α-syn 的表观亲和力至少比单体重组 α-syn 高 800 倍，并且对人 PD 脑组织有强烈的偏好[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cinpanemab 相关抗体:
体内研究
(In Vivo)

Cinpanemab (30 mg/kg; 腹腔注射) 改善 α-syn PFF 接种小鼠模型中的 PD 样表型[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6JRccHsd WT mice, transgenic M83 mice expressing human α-syn A53T, and transgenic bacterial artificial chromosome mice expressing human α-syn A53T were anesthetized and stereotaxically injected with α-syn preformed fibrils (PFFs) into the right forebrain[2]
Dosage: 30 mg/kg
Administration: Intraperitoneal (i.p.) injections 2-3 times prior to α-syn PFF injection and weekly post-injection until time of sacrifice
Result: Attenuated the spreading of α-syn pathology, rescued motor impairments, and reduced the loss of dopamine transporter density in dopaminergic terminals in striatum.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cinpanemab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cinpanemab2094516-02-4BIIB054 Anti-Alpha-synuclein Reference Antibody (cinpanemab)BIIB 054BIIB-054α-synucleinα-SynParkinson's diseaseInhibitorinhibitorinhibit

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