2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor Adrenergic Receptor
  4. Clebopride

Clebopride 是一种口服有效的 dopamine Receptor 拮抗剂。Clebopride 作用于多巴胺 D2 受体，具有止吐和促动力作用。Clebopride 可用于功能性胃肠病研究。

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Clebopride

Clebopride Chemical Structure

CAS No. : 55905-53-8

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Clebopride 的其他形式现货产品:

Customer Review

Other Forms of Clebopride:

Clebopride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Dopamine Receptor 亚型特异性产品:

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Clebopride is an orally active dopamine Receptor antagonist. Clebopride acts on dopamine D2 receptors and has antiemetic and prokinetic effects. Clebopride can be used in the study of functional gastrointestinal disorders[1][2][3][4].

体外研究
(In Vitro)

Clebopride (0.1 nM-10μM，30 分钟) 在牛脑膜中，对 D2 多巴胺受体 (Ki: 3.5 nM) 和 α2 肾上腺素受体 (Ki: 780 nM) 具有选择性结合[3]。
Clebopride 对 ETS 诱导的胃条收缩具有抑制作用 (IC50: 0.43 μM)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clebopride 相关抗体:
药代动力学
(Parmacokinetics)[4]
Species Dose Route Indicator value
Dog 10 mg/kg i.v. T1/2 (Distribution) 18 min
Rat 10 mg/kg i.v. T1/2 (Distribution) 12.89 min
Rat 10 mg/kg p.o. T1/2 (Elimination) 27 min
Dog 10 mg/kg i.v. T1/2 (Elimination) 104 min
Rat 10 mg/kg i.v. T1/2 (Elimination) 46.80 min
Rat 10 mg/kg p.o. AUC 0.319 μg·h/mL
Dog 10 mg/kg i.v. Vd 3.17 L/kg
Rat 10 mg/kg i.v. Vd 1.62 L/kg
Rat 10 mg/kg i.v. CL 32.26 mL/min/kg
分子量

373.88

Formula

C20H24ClN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Clebopride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clebopride55905-53-8Dopamine ReceptorAdrenergic ReceptorBeta ReceptorDopaminegastrointestinal disordersInhibitorinhibitorinhibit

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