2. Inhibitory Antibodies
  3. Concizumab

Concizumab  (Synonyms: NN 7415; mAb 2021; Anti-TFPI Recombinant Antibody)

目录号: HY-P99283 纯度: 95.00%
COA

摩尔计算器

Concizumab 是一种 抗 TFPI 单克隆抗体 (IgG4 型)，可与 TFPI 的 Kunitz 型蛋白酶抑制剂 (KPI) 2 结构域结合，从而阻断该结构域与 FXa 活性位点的相互作用。Concizumab 可用于血友病的研究。

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Concizumab Chemical Structure

Concizumab Chemical Structure

CAS No. : 1312299-39-0

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规格 价格 是否有货 数量
1 mg ￥2800
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5 mg ￥7200
In-stock
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Customer Review

Concizumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that binds to the Kunitz-type protease inhibitor (KPI) 2 structural domain of TFPI, thereby blocking the interaction of this structural domain with the FXa active site. Concizumab can be used in the study of haemophilia[1][2].

IC50 & Target

TFPI[1][2].
体外研究
(In Vitro)

Concizumab 以浓度依赖性方式增加凝血酶峰值[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Concizumab 相关抗体:
体内研究
(In Vivo)

Concizumab (i.v./s.c.) 阻断 TFPI 与食蟹猴中 FXa 活性位点的相互作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys (target mediated drug disposition (TMDD) model)[2].
Dosage: 20mg/kg or 200 mg/kg
Administration: Intravenous injection/subcutaneous injection
Result: Showed a high bioavailability (93%) and the absorption half-life is estimated to be 72 h.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

  • 摩尔计算器

  • 稀释计算器

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Concizumab1312299-39-0NN 7415 mAb 2021 Anti-TFPI Recombinant AntibodyNN7415NN-7415mAb2021mAb 2021mAb-2021Othershemophilia(KPI) 2FXathrombinInhibitorinhibitorinhibit

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