2. GPCR/G Protein
  3. GCGR
  4. Cotadutide

Cotadutide  (Synonyms: MEDI0382)

目录号: HY-P2231
产品使用指南

摩尔计算器

Cotadutide (MEDI0382) 是一种有效的胰高血糖素样肽-1 (GLP-1) 和胰高血糖素受体 (GCGR) 双重激动剂，EC50 值分别为 6.9 pM 和 10.2 pM。Cotadutide 可促进减肥，控制血糖，以及减轻纤维化。Cotadutide 可用于肥胖和 2 型糖尿病 (T2D) 的研究。

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Cotadutide Chemical Structure

Cotadutide Chemical Structure

CAS No. : 1686108-82-6

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规格 是否有货
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Cotadutide 的其他形式现货产品:

Customer Review

Other Forms of Cotadutide:

Cotadutide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D)[1][2][3].

IC50 & Target

EC50: 6.9 pM (GLP-1); 10.2 pM (GCGR)[1]
体外研究
(In Vitro)

Cotadutide stimulates a concentration-dependent increase in cAMP accumulation in rat (INS-1 832/3) and human (EndoC-βH1) β-cell lines (EC50: 226 pM and 1051 pM, respectively ), as well as rat, mouse and human hepatocytes (EC50: 462 pM, 840 pM, 1447 pM, respectively)[1].
Cotadutide (100 pM-1 μM) potentiates glucose-stimulated insulin secretion in the rat (INS-1 832/3) pancreatic β‐cell line and increases glucose output in rat hepatocytes[1].
Cotadutide (100 nM, 2 h) induces mitochondrial turnover and enhances mitochondrial function in mouse primary hepatocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cotadutide 相关抗体:
体内研究
(In Vivo)

Cotadutide (10 nmol/kg, s.c., once) suppresses food intake in DIO mice relative to vehicle‐treated controls[1].
Cotadutide (10 or 30 nmol/kg, s.c., once daily for 14-16 weeks) reduces body weight in DIO mice[1].
Cotadutide (30 nmol/kg, s.c., once a day for 6 weeks) reduces hepatic fibrosis and inflammation in in ob/ob AMLN NASH mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obesity (DIO) mice[1]
Dosage: 10 nmol/kg
Administration: Subcutaneousinjection (s.c.)
Result: Showed a redction of food intake in mice after an acute administration.
Animal Model: Diet-induced obesity (DIO) mice[1]
Dosage: 10 or 30 nmol/kg
Administration: Subcutaneousinjection (s.c.)
Result: Reduced body weight and food intake, and improved glucose tolerance in DIO mice.
Clinical Trial
分子量

3728.09

Formula

C167H252N42O55
CAS 号
Sequence

1'-{palmtoyl-Glu}; His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys-Ser-Glu-Tyr-Leu-Asp-Ser-Glu-Arg-Ala-Arg-Asp-Phe-Val-Ala-Trp-Leu-Glu-Ala-Gly-Gly (Amide bridge: Glu1'-Lys10)
Sequence Shortening

1'-{palmtoyl-Glu}; HSQGTFTSDKSEYLDSERARDFVAWLEAGG (Amide bridge: Glu1'-Lys10)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cotadutide 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cotadutide1686108-82-6MEDI0382MEDI 0382MEDI-0382GCGRGlucagon ReceptorFOODuptakediabeteT2DobesityNASHfibrosisinflammationInhibitorinhibitorinhibit

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