2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Aminopeptidase Phosphatase Angiotensin-converting Enzyme (ACE) DNA/RNA Synthesis
  4. Cyanostatin B

Cyanostatin B，一种蓝藻脂肽，是一种亮氨酸氨肽酶 (LAP) 抑制剂 (IC50 = 12 ng/mL)。Cyanostatin B 是蛋白磷酸酶 (PP2A) 的弱抑制剂，且对血管紧张素转换酶 (ACE) 也有弱抑制性，其 IC50 值为 130 μg/mL。Cyanostatin B 对卤虫无毒性，但能在体外对人类肝细胞产生细胞毒性和遗传毒性。Cyanostatin B 抑制了 HepG 细胞增殖、诱导了 DNA 单链断裂和引起了基因组的不稳定性。

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Custom Peptide Synthesis

Cyanostatin B

Cyanostatin B Chemical Structure

CAS No. : 850131-23-6

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Cyanostatin B 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC50 = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC50 value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability.[1][2].

体外研究
(In Vitro)

Cyanostatin B (0-75 μg/mL, 24 小时) 对卤虫幼体 (无节幼体) 无毒性[1]。
Cyanostatin B (0-10 μg/mL，24-48 小时) 在 HepG2 细胞中暴露 72 小时后，表现出浓度依赖性的细胞增殖抑制[2]。
Cyanostatin B (0-1 μg/mL，24-48 小时) 在 HepG2 细胞中诱导 DNA 单链断裂 (SSB)，但不诱导 DNA 双链断裂 (DSB)[2]。
Cyanostatin B (1 μg/mL，24-72 小时) 具有致染色体断裂作用，导致 HepG2 细胞染色体断裂或整个染色体丢失[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cyanostatin B 相关抗体:
分子量

753.92

Formula

C40H59N5O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cyanostatin B 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyanostatin B850131-23-6AminopeptidasePhosphataseAngiotensin-converting Enzyme (ACE)DNA/RNA SynthesisCyanotoxinMicrogininDNA damageMicrocystisOligopeptidesGenotoxicInhibitorinhibitorinhibit

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