1. Autophagy
  2. Autophagy
  3. Cytochalasin E

Cytochalasin E  (Synonyms: 细胞松弛素E)

目录号: HY-N6772 纯度: 99.90%
COA 产品使用指南

Cytochalasin E 是一种含有曲霉衍生真菌代谢产物的环氧化物,抑制血管生成和肿瘤生长,Cytochalasin E 是一种有效的肌动蛋白解聚剂,能结合肌动蛋白丝的倒刺端并盖住,以防止肌动蛋白伸长。

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Cytochalasin E Chemical Structure

Cytochalasin E Chemical Structure

CAS No. : 36011-19-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation[1][2].

体外研究
(In Vitro)

Cytochalasin E prominently inhibits the growth of A549 cells in a dose-dependent manner[3].
Cytochalasin E could induce the up-regulation of autophagy-related protein (LC3-II) and SQSTM1/p62[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

495.56

Formula

C28H33NO7

CAS 号
性状

固体

颜色

White to off-white

中文名称

细胞松弛素E

结构分类
初始来源

the fungus R. necatrix

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.90%

参考文献

Cytochalasin E 相关分类

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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