2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Dalazatide

Dalazatide  (Synonyms: ShK-186)

目录号: HY-P3507
产品使用指南

摩尔计算器

Dalazatide (ShK-186) 是一种特异性的 Kv1.3 钾通道肽抑制剂。Dalazatide 可用于自身免疫性疾病，如多发性硬化症 (MS)、红斑狼疮、银屑病、类风湿性关节炎、1 型糖尿病和炎症性肠病的研究。

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Custom Peptide Synthesis

Dalazatide Chemical Structure

Dalazatide Chemical Structure

CAS No. : 1081110-69-1

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Dalazatide 的其他形式现货产品:

Customer Review

Other Forms of Dalazatide:

Dalazatide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease[1][2][3].

体外研究
(In Vitro)

Dalazatide (ShK-186) (0-1000 pM) 以剂量依赖的方式阻断卵巢特异性 GFP+ 效应记忆 T (Tem) 细胞中的 Kv1.3 电流，Kd 为 65 ± 5 pM[3]。
Dalazatide (0-100 nM; 3 days) 以剂量依赖的方式抑制 CCR7− T 细胞增殖[3]。
Dalazatide (100 nM; 30 min) 通过抑制钙信号通路固定炎症部位的效应记忆 T (Tem) 细胞，从而阻止 β1 整合素激活[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dalazatide 相关抗体:

Cell Proliferation Assay[3]

Cell Line: CCR7− T cell[3]
Concentration: 0-100 nM
Incubation Time: 3 days
Result: Inhibited cell proliferation with an IC50 of 180 ± 37 pM.
体内研究
(In Vivo)

Dalazatide (ShK-186) (100 μg/kg; s.c.; once) 在大鼠中抑制延迟型超敏反应，并抑制 Tem 细胞的体内运动和激活[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats rats, delayed-type hypersensitivity (DTH) model[3]
Dosage: 100 μg/kg
Administration: Subcutaneous injection, once
Result: Reduced DTH at all time points compared to rats given saline injections. Suppressed the proliferation of the Tem cells.
Clinical Trial
分子量

4442.08

Formula

C184H296N57O55PS7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

Dalazatide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dalazatide1081110-69-1ShK-186ShK186ShK 186Potassium ChannelKcsAmultiple sclerosis (MS)lupus erythematosuspsoriasisrheumatoid arthritistype 1 diabetesinflammatory bowel diseaseInhibitorinhibitorinhibit

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