2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. DAPI

DAPI  (Synonyms: 4',6-Diamidino-2-phenylindole)

目录号: HY-D2868 纯度: 98.01%
COA 产品使用指南 技术支持

DAPI (Compound 3) 是一种酸敏感离子通道 3 (ASIC3) 抑制剂。DAPI 是通过与 ASIC3 结合，阻断通道功能。DAPI 可用于慢性疼痛治疗的研究。

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DAPI

DAPI Chemical Structure

CAS No. : 47165-04-8

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规格 价格 是否有货 数量
1 mg ￥1560
In-stock
5 mg ￥3120
In-stock
10 mg ￥5120
In-stock
25 mg 现货 询价
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

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Other Forms of DAPI:

DAPI 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 97 篇科研文献

IF

    DAPI purchased from MCE. Usage Cited in: Pharmaceuticals (Basel). 2022 Jun 6;15(6):721.

    The nuclei are counterstained with DAPI (10 μM) in the dark for 10 min at room temperature. Fluorescence is monitored using confocal microscope, and foci of phospho-H2A.X was quantified using ImageJ software.

    DAPI purchased from MCE. Usage Cited in: Acta Pharmacol Sin. 2021 Jul;42(7):1111-1123.  [Abstract]

    Mice intestine tissues sections were incubated with a TUNEL reaction mixture for 1 h at 37 °C in the dark. Next, the sections are stained with 0.1 μg/mL DAPI.

    DAPI purchased from MCE. Usage Cited in: Oncotargets Ther. 2020 Oct 6;13:9941-9952.  [Abstract]

    Human GC MGC-803 and NCI-N87 cells are seeded into 24-well plates with glass slide for 24h in RPMI-1640 medium. And 0.1% DAPI staining is performed against light for 30 minutes.

    DAPI purchased from MCE. Usage Cited in: Acta Biomater. 2019 Sep 15:96:468-479.  [Abstract]

    CLSM observations of tested Cy5-nanocomplexes incubated with RAW 264.7 macrophages show the fluorescent distributions of DAPI, nanocomplexes, and ROS (DCFH-DA) in the presence and absence NIR treatment.

    DAPI purchased from MCE. Usage Cited in: Phytomedicine. 2020 Mar;68:153146.  [Abstract]

    MC3T3-E1 cells incubated with 1 μg/ml DAPI dihydrochloride for 5 min and observed them under a fluorescence microscope. Effects of sweroside on ER-α and GPR30 expressions by immunofluorescence, white and yellow arrows mean target protein distribution in the cell nuclei and membrane, respectively.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment[1].

    分子量

    277.32

    Formula

    C16H15N5
    CAS 号
    性状

    固体

    颜色

    Light yellow to yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    -20°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 9.09 mg/mL (32.78 mM; ultrasonic and adjust pH to 3 with 1 M HCL; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.6059 mL 18.0297 mL 36.0594 mL
    5 mM 0.7212 mL 3.6059 mL 7.2119 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    DAPI 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.6059 mL 18.0297 mL 36.0594 mL 90.1486 mL
    5 mM 0.7212 mL 3.6059 mL 7.2119 mL 18.0297 mL
    10 mM 0.3606 mL 1.8030 mL 3.6059 mL 9.0149 mL
    15 mM 0.2404 mL 1.2020 mL 2.4040 mL 6.0099 mL
    20 mM 0.1803 mL 0.9015 mL 1.8030 mL 4.5074 mL
    25 mM 0.1442 mL 0.7212 mL 1.4424 mL 3.6059 mL
    30 mM 0.1202 mL 0.6010 mL 1.2020 mL 3.0050 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    DAPI47165-04-84',6-Diamidino-2-phenylindoleSodium ChannelNa channelsNa+ channelsASIC3painSD ratsCFAInhibitorinhibitorinhibit

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