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DB772 是一种牛病毒性腹泻病毒（BVDV）抑制剂。DB772 还具有抗朊病毒活性。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 DB772 hydrate 通常具有更好的水溶性和稳定性。

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DB772 Chemical Structure

DB772 Chemical Structure

CAS No. : 1451058-50-6

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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100 mg
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Customer Review

Other Forms of DB772:

DB772 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity[1].

体外研究
(In Vitro)

DB772 hydrate (0-100 μM, 96 hours) can inhibit replication of the viruses BVDV2 and BDV at concentrations greater than 0.2 μM, Bungowannah virus replication at concentrations greater than 0.01 μM, and HoBi virus replication greater than 1.65 μM[2].
DB772 hydrate has antiprion activity with CC50 (50% cytotoxic concentration) value of 3.8 μM, TC-EC50 (50% tissue culture effective concentration) value of 0. 8 μM and inhibits PrPSc accumulation in sheep microglia[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DB772 相关抗体:

Cell Viability Assay[3]

Cell Line: PrPSc-positive and -negative cell lines of human telomerase-immortalized (hTERT) ovine microglia
Concentration: 1 μM
Incubation Time: 4 days
Result: Showed no significant effect on cell viability with 96.4% cell viability.
Significantly reduced PrPSc-positive spots by 65.8% and completely inhibited PrPSc accumulation in scrapie-infected primary ovine microglia at 4 μM.
分子量

401.29

Formula

C20H18Cl2N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 10 mg/mL (24.92 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4920 mL 12.4598 mL 24.9196 mL
5 mM 0.4984 mL 2.4920 mL 4.9839 mL
查看完整储备液配制表

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

DB772 相关分类

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4920 mL 12.4598 mL 24.9196 mL 62.2991 mL
5 mM 0.4984 mL 2.4920 mL 4.9839 mL 12.4598 mL
10 mM 0.2492 mL 1.2460 mL 2.4920 mL 6.2299 mL
15 mM 0.1661 mL 0.8307 mL 1.6613 mL 4.1533 mL
20 mM 0.1246 mL 0.6230 mL 1.2460 mL 3.1150 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DB7721451058-50-6DB 772DB-772OthersbovineviraldiarrheavirusInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
DB772
目录号：
HY-114621
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