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  3. Dextran T4 (MW 4,000)

Dextran T4 (MW 4,000)  (Synonyms: 右旋糖酐T4(MW 3200-4800); Dextran 4; Dextran D4; Dextran T4(MW 3200-4800))

目录号: HY-112624J
COA 产品使用指南 技术支持

Dextran 4,000 是一种黏液流变学调节剂。Dextran 4,000 的葡聚糖分子通过渗透效应和氢键替代作用,能够降低黏液交联密度,并通过破坏黏液中 DNA-黏蛋白网络结构发挥降低黏弹性、提升黏液纤毛/咳嗽清除指数。Dextran 4,000 具有改善囊性纤维化 (CF) 痰液的流变特性及清除能力,可用于黏液滞留性呼吸道疾病的吸入疗法或雾化递送的研究。Dextran 系列化合物还是一种天然多糖类药物载体剂,可通过酯键、酰胺键或点击化学等共价结合方式与药物连接,或自组装形成纳米粒子、水凝胶等载体。Dextran 具有生物可降解性和生物相容性,可实现药物的靶向递送与控释。Dextran 的衍生物可延长药物半衰期、提高局部浓度及降低免疫清除的活性。

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Dextran T4 (MW 4,000) Chemical Structure

Dextran T4 (MW 4,000) Chemical Structure

CAS No. : 9004-54-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance[1][2][3].

体外研究
(In Vitro)

Dextran 4,000 (0.4% (4 mg/mL)、4% (40 mg/mL);30 min) 在囊性纤维化痰液及健康狗粘液的体外实验中,可降低痰液粘弹性、减少可纺性并提升粘液纤毛清除指数 (MCI) 及咳嗽清除指数 (CCI)[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3200-4800

同用名

右旋糖酐T4(MW 3200-4800); Dextran 4; Dextran D4; Dextran T4(MW 3200-4800)

Formula

(C6H10O5)n

CAS 号
性状

固体

颜色

White to off-white

中文名称

右旋糖酐4;右旋糖酐D4;右旋糖酐T4(MW 3200-4800)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验: 

H2O 中的溶解度 : ≥ 100 mg/mL

* "≥" means soluble, but saturation unknown.

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

参考文献

Dextran T4 (MW 4,000) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Dextran T4 (MW 4,000)
目录号:
HY-112624J
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