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  3. Dextran T3 (MW 3,000)

Dextran T3 (MW 3,000)  (Synonyms: 右旋糖酐T3(MW 2400-3600); Dextran 3; Dextran D3; Dextran T3(MW 2400-3600))

目录号: HY-112624I
COA 产品使用指南 技术支持

Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) 是一种神经示踪剂及肠道通透性探针,可通过被动扩散机制在神经元轴突中顺行/逆行移动。Dextran T3 (MW 3,000) 在霍乱毒素诱导的肠上皮细胞骨架紊乱环境中,能够跨膜渗透。Dextran T3 (MW 3,000) 作为荧光标记物快速标记发育中的神经元 (如非洲爪蟾视网膜神经节细胞) 及评估肠道屏障功能,可用于研究神经解剖学中轴突运输及肠道病理生理学中通透性变化。Dextran 系列化合物还是一种天然多糖类药物载体剂,可通过酯键、酰胺键或点击化学等共价结合方式与药物连接,或自组装形成纳米粒子、水凝胶等载体。Dextran 具有生物可降解性和生物相容性,可实现药物的靶向递送与控释。Dextran 的衍生物可延长药物半衰期、提高局部浓度及降低免疫清除的活性。

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Dextran T3 (MW 3,000) Chemical Structure

Dextran T3 (MW 3,000) Chemical Structure

CAS No. : 9004-54-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) is a neural tracer and intestinal permeability probe that can move anterogradely and retrogradely in neuronal axons by passive diffusion. Dextran T3 (MW 3,000) is able to permeate across the intestinal epithelial cell membrane in the presence of cholera toxin-induced cytoskeletal disturbance. Dextran T3 (MW 3,000) is used as a fluorescent marker to rapidly label developing neurons (such as Xenopus retinal ganglion cells) and to assess intestinal barrier function. It can be used to study axonal transport in neuroanatomy and permeability changes in intestinal pathophysiology. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance[1][2][3].

体内研究
(In Vivo)

异硫氰酸荧光素 (FITC) 标记的 Dextran T3 (MW 3,000) (FITC-D3) 可作为探针分子,用于探究霍乱毒素对大鼠肠道通透性影响。一组提前 90 分钟用 Cholera toxin (HY-P1446) 胃管口服预处理,再注射 FITC-D3 (1 mg/mL,1 mL;腹腔注射);另一组在回肠远端局部联用 Cholera toxin 与 FITC-D3,进行通透性测量。最后通过门静脉采血并利用荧光分光计检测 FITC-D3 浓度以评估肠道通透情况 (Ex=483 nm,Em=517 nm)[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2400-3600

同用名

右旋糖酐T3(MW 2400-3600); Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)

Formula

(C6H10O5)n

CAS 号
性状

固体

颜色

White to off-white

中文名称

右旋糖酐3;右旋糖酐D3;右旋糖酐T3(MW 2400-3600)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验: 

H2O 中的溶解度 : ≥ 100 mg/mL

* "≥" means soluble, but saturation unknown.

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

参考文献

Dextran T3 (MW 3,000) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dextran T3 (MW 3,000)
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