2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. Dextran T5 (MW 5,000)

Dextran T5 (MW 5,000)  (Synonyms: 右旋糖酐T5(MW 4500-5500); Dextran 5; Dextran D5; Dextran T5(MW 4500-5500))

目录号: HY-112624K
COA 产品使用指南 技术支持

Dextran T5 (MW 5,000) 是一种硫酸化多糖类抗凋亡与促自噬剂。Dextran T5 (MW 5,000) 具有硫酸化基团，通过模拟内源性糖胺聚糖与细胞膜相互作用，通过抑制线粒体凋亡通路、延迟 DNA 碎片化，发挥抗凋亡活性。Dextran T5 (MW 5,000) 同时促进 LC3-I 向 LC3-II 转化及自噬体形成以激活自噬通路。Dextran T5 (MW 5,000) 可延长 CHO 细胞存活周期并使重组促红细胞生成素 (EPO) 产量提升。Dextran 系列化合物还是一种天然多糖类药物载体剂，可通过酯键、酰胺键或点击化学等共价结合方式与药物连接，或自组装形成纳米粒子、水凝胶等载体。Dextran 具有生物可降解性和生物相容性，可实现药物的靶向递送与控释。Dextran 的衍生物可延长药物半衰期、提高局部浓度及降低免疫清除的活性。

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Dextran T5 (MW 5,000) Chemical Structure

Dextran T5 (MW 5,000) Chemical Structure

CAS No. : 9004-54-0

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Dextran T5 (MW 5,000) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dextran T5 (MW 5,000) is a sulfated polysaccharide anti-apoptotic and autophagic agent. Dextran T5 (MW 5,000) has sulfated groups and interacts with cell membranes by mimicking endogenous glycosaminoglycans, inhibiting the mitochondrial apoptotic pathway and delaying DNA fragmentation to exert anti-apoptotic activity. Dextran T5 (MW 5,000) also promotes the conversion of LC3-I to LC3-II and the formation of autophagosomes to activate the autophagic pathway. Dextran T5 (MW 5,000) can prolong the survival cycle of CHO cells and increase the production of recombinant erythropoietin (EPO). The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance[1][2][3].

体外研究
(In Vitro)

Dextran T5 (MW 5,000) (100 mg/L；4 天) 增加 CHO 细胞的活细胞数量，提升重组 EPO 产量[1]。
Dextran T5 (MW 5,000) (100 mg/L；48 h) 抑制 CHO 细胞的 DNA 碎片化、抑制凋亡[1]。
Dextran T5 (MW 5,000) (100 mg/L；48 h) 在 CHO 和 HeLa 细胞中降低 p53 表达、升高 Hsc70，并增加 HeLa 细胞中 HcRed-hLC3 标记的自噬体数量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dextran T5 (MW 5,000) 相关抗体:

Apoptosis Analysis[1]

Cell Line: CHO cells producing EPO
Concentration: 100 mg/L
Incubation Time: 48 h
Result: Reduced early apoptosis and late apoptosis/necrosis, resulted 2-fold decrease in DNA fragmentation in DS-treated cells.
分子量

4500-5500

Formula

(C6H10O5)n
CAS 号
性状

固体

颜色

White to off-white

中文名称

右旋糖酐5；右旋糖酐D5；右旋糖酐T5(MW 4500-5500)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Dextran T5 (MW 5,000) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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