1. Anti-infection
  2. Parasite
  3. DHQZ 36

DHQZ 36 是一种逆行运输的有效抑制剂。DHQZ 36 以 EC50 值为13.63 μM 来抑制巨噬细胞中 Leishmania amazonensis 的感染。DHQZ 36 具有有效的抗寄生虫活性。

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DHQZ 36 Chemical Structure

DHQZ 36 Chemical Structure

CAS No. : 1542098-94-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages with an EC50 of 13.63 μM. DHQZ 36 has potent anti-parasite activity[1].

IC50 & Target

EC50: 13.63 μM (Leishmania amazonensis)[1]

体外研究
(In Vitro)

With increasing concentrations of DHQZ 36 there is a significant diminution in the size of parasitophorous vacuoles (LPVs), vacuole sizes are reduced by 30% at 50 μM. These parasites also cause a reduction in the number of parasites per macrophage. Significant parasite loss is observed with as low as 5 μM after treatment with DHQZ 36. Parasites are unable to recover growth when treated with DHQZ 36 at concentrations at or above 12.5 μM[1].
DHQZ 36 causes over 40% reduction in secreted of parasite proteins. DHQZ 36 causes a reversal in Leishmania induced suppression of IL-6 release by infected cells after LPS activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

384.44

Formula

C21H18F2N2OS

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

DHQZ 36 相关分类

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  • Do most proteins show cross-species activity?

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DHQZ 36
目录号:
HY-123601
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