2. Others Metabolic Enzyme/Protease Immunology/Inflammation
  3. Isotope-Labeled Compounds Cytochrome P450 Aryl Hydrocarbon Receptor
  4. Dibenzothiophene-d8

Dibenzothiophene-d8  (Synonyms: 二苯并噻吩-d8)

目录号: HY-B0973S
产品使用指南 技术支持

Dibenzothiophene-d8 是 Dibenzothiophene (HY-B0973) 的氘代物。 Dibenzothiophene 是一种口服活性的非竞争性 CYP1A 抑制剂。Dibenzothiophene 抑制 CYP1A 介导的 EROD 活性，Km 为 0.592 μM。Dibenzothiophene 与 AHR 通路相互作用。Dibenzothiophene 增强 β-naphthoflavone (HY-114740) 的胚胎毒性。Dibenzothiophene 对小鼠有急性毒性。Dibenzothiophene 主要用于研究生物体发育毒性的机制。

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Dibenzothiophene-d<sub>8</sub> Chemical Structure

Dibenzothiophene-d8 Chemical Structure

CAS No. : 33262-29-2

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规格 价格 是否有货 数量
1 mg 询价
5 mg ￥1452
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Other Forms of Dibenzothiophene-d8:

Dibenzothiophene-d8 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dibenzothiophene-d8 is the deuterium labeled Dibenzothiophene (HY-B0973). Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with Km of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dibenzothiophene-d8 相关抗体:
分子量

192.31

同用名

二苯并噻吩-d8

Formula

C12D8S
CAS 号
非标记 CAS
中文名称

二苯并噻吩-d8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dibenzothiophene-d8 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dibenzothiophene-d833262-29-2二苯并噻吩-d8Isotope-Labeled CompoundsCytochrome P450Aryl Hydrocarbon ReceptorCYPsAhRInhibitorinhibitorinhibit

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