2. NF-κB Immunology/Inflammation
  3. NF-κB Interleukin Related
  4. Dimethyl diacetyl cystinate

Dimethyl diacetyl cystinate  (Synonyms: DACDM)

目录号: HY-W550315
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Dimethyl diacetyl cystinate (DACDM) 是一种强效的 NF-κB 抑制剂。Dimethyl diacetyl cystinate 通过增加细胞内氧化型谷胱甘肽 (GSSG) 的含量来改变细胞内的氧化还原平衡，竞争性地阻止被激活的 NF-κB 与 DNA 的结合，从而抑制如 IL-1κ 等炎症因子的产生。Dimethyl diacetyl cystinate 有望用于 UVB 引发的皮肤炎症及相关氧化应激疾病的研究。

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Dimethyl diacetyl cystinate

Dimethyl diacetyl cystinate Chemical Structure

CAS No. : 32381-28-5

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规格 价格 是否有货 数量
25 mg ￥446
1 - 2 周
50 mg ￥669
1 - 2 周
100 mg ￥1037
1 - 2 周
250 mg ￥1866
1 - 2 周
1 g ￥5225
1 - 2 周
5 g   询价  
10 g   询价  

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Dimethyl diacetyl cystinate 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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  • 纯度 & 产品资料

  • 参考文献

生物活性

Dimethyl diacetyl cystinate (DACDM) is a potent NF-κB inhibitor. Dimethyl diacetyl cystinate shifts the intracellular redox balance toward the oxidized state by increasing intracellular oxidized glutathione (GSSG) content, competitively blocking the binding of activated NF-κB to DNA, thereby inhibiting the production of inflammatory factors such as IL-1κ. Dimethyl diacetyl cystinate is promising for research of UVB-induced skin inflammation and related oxidative stress diseases[1].

分子量

352.43

Formula

C12H20N2O6S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dimethyl diacetyl cystinate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethyl diacetyl cystinate32381-28-5DACDMNF-κBInterleukin RelatedNuclear factor-κBNuclear factor-kappaBILGSSGskin inflammationoxidative stress diseasesInhibitorinhibitorinhibit

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