1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase
  3. Dutogliptin tartrate

Dutogliptin tartrate (Synonyms: PHX-1149)

目录号: HY-10286A
产品使用指南

Dutogliptin tartrate (PHX-1149) 是一种口服有效的选择性二肽基肽酶-4 (DPP4) 抑制剂,可用于治疗 2 型糖尿病。

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Dutogliptin tartrate Chemical Structure

Dutogliptin tartrate Chemical Structure

CAS No. : 890402-81-0

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Description

Dutogliptin tartrate (PHX-1149) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.

IC50 & Target

DPP4[1]

In Vivo

Dutogliptin exhibits low plasma protein binding (11%) and is rapidly absorbed with a Tmax of 3-4 h and a half-life of 10-13 h. Dutogliptin is metabolically stable and does not inhibit or induce the activity of major CYP450s[2].

Molecular Weight

391.18

Formula

C₁₄H₂₆BN₃O₉

CAS No.

890402-81-0

SMILES

O=C(CN[C@@H]1CCNC1)N(CCC2)[C@@H]2B(O)O.O[C@H]([C@H](C(O)=O)O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DutogliptinPHX-1149PHX1149PHX 1149Dipeptidyl PeptidaseDPPDPP4diabetesmellitusInhibitorinhibitorinhibit

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产品名称:
Dutogliptin tartrate
目录号:
HY-10286A
需求量: