2. Autophagy Apoptosis
  3. Autophagy Apoptosis
  4. EAD1

EAD1 是一种有效的自噬 (autophagy) 抑制剂，在肺癌和胰腺癌细胞中具有抗增殖活性。EAD1 还诱导凋亡 (apoptosis)。

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EAD1 Chemical Structure

EAD1 Chemical Structure

CAS No. : 1644388-26-0

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EAD1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EAD1 is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 also induces apoptosis[1].

体外研究
(In Vitro)

EAD1 (0-200 μM; 72 hours) has antiproliferative activity against human cancer cell lines[1].
EAD1 (5-75 μM; 24 hours) induces apoptosis in the H460 cells in a concentration-dependent manner[1].
EAD1 (1-25 μM; 24 hour) increases the punctate LC3 signal in H460 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EAD1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: H460 and HCC827 nonsmall cell lung cancer (NSCLC) and BxPC3 pancreatic cancer cells
Concentration: 0, 50, 100, 150, 200 μM
Incubation Time: 72 hours
Result: IC50s of 11, 7.6, and 5.8 μM for H460, HCC827, and BxPC3 cells, respectively.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 5, 25, 50, and 75 μM
Incubation Time: 24 hours
Result: Induction of apoptosis.

Western Blot Analysis[1]

Cell Line: H460 cells
Concentration: 1, 2.5, 5, 10, 25 μM
Incubation Time: 24 hours
Result: Caused concentration and time-dependent increases in LC3-II levels.
分子量

484.42

Formula

C24H27Cl2N7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EAD1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EAD11644388-26-0EAD 1EAD-1AutophagyApoptosisantiproliferativelungpancreaticcancerInhibitorinhibitorinhibit

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