2. GPCR/G Protein
  3. Guanylate Cyclase
  4. Ebselen oxide

Ebselen oxide，Ebselen的 硒酮类似物，通过共价修饰二鸟苷酸环化酶 (DGC) 以抑制 c-di-GMP 受体相互作用并降低 DGC 活性。Ebselen oxide 还抑制 Pseudomonas aeruginosa 产生藻酸盐 (alginate)，IC50 为 14 μM。Ebselen oxide 抑制 HDAC1、HDAC3、HDAC4、HDAC5、HDAC6、HDAC7、HDAC8 和 HDAC9 (IC50 范围为 0.2 至 4.7 μM)。

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Ebselen oxide Chemical Structure

Ebselen oxide Chemical Structure

CAS No. : 104473-83-8

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Ebselen oxide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ebselen oxide, the selenone analogue of Ebselen, covalently modifies diguanylate cyclase (DGC) to inhibit c-di-GMP-receptor interactions and reduces DGC activity. Ebselen oxide also inhibits alginate production (IC50=14 μM) by Pseudomonas aeruginosa. Ebselen oxide inhibits HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9 (IC50 ranging from 0.2 to 4.7 μM)[1][2][3].

体外研究
(In Vitro)

Ebselen oxide, is a covalent inhibitor of c-di-GMP allosteric binding to I-site containing proteins, diguanylate cyclase (DGC) activity[1].
Ebselen oxide inhibits diguanylate cyclase from synthesizing c-di-GMP. Ebselen oxide exhibits increased potency on HDAC8 (IC50=0.2 μM) in comparison with Ebselen[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ebselen oxide 相关抗体:
分子量

290.18

Formula

C13H9NO2Se
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥98.0%

COA (175 KB)

产品使用指南 (1538 KB)
参考文献

Ebselen oxide 相关分类

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Keywords:

Ebselen oxide104473-83-8Guanylate Cyclasecovalentc-di-GMPallostericdiguanylate cyclasealginate synthesisInhibitorinhibitorinhibit

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