Eculizumab  (Synonyms: 依库珠单抗; Anti-Human C5, Humanized Antibody)

Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab inhibits the cleavage of C5 into C5a and C5b and inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in mice. Eculizumab can be used in hemolysis studies^[1][2].

Human IgG2 kappa

Human IgG2 kappa, Isotype Control

Human

Complement C5

Eculizumab (3-100 μg/mL) 在体外 MFS 模型中可完全防止 MAC 沉积、末端轴突神经丝丢失和突触周围 Schwann 细胞的损伤，并抑制 MEPP 频率的增加、肌纤维的异步抽搐和“静默” NMJ 的发生，并以浓度依赖性方式防止 CGM3/NHS 引起的收缩力丧失^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Eculizumab (200 μg；静脉注射；在腹膜内注射 NHS 之前) 在 Miller Fisher 综合征 (MFS) 小鼠模型中完全阻止了虚弱、呼吸困难的发生，几乎完全阻止了“沉默” NMJ 的发生，并保留了正常收缩和 NMJ 功能^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

727  [NCBI]

P01031

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

145.74 kDa

219685-50-4

液体

Colorless to light yellow

依库珠单抗

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  IgG2-kappa

• [1]. Halstead SK, et al. Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model. Brain. 2008 May;131(Pt 5):1197-208.  [Content Brief]

  [2]. Eline A Dubois,et al. Eculizumab. Br J Clin Pharmacol. 2009 Sep;68(3):318-9.  [Content Brief]