1. Protein Tyrosine Kinase/RTK
  2. c-Fms
  3. Eflapegrastim


目录号: HY-P99913

Eflapegrastim 是一种人源化 IgG4 单抗 ,也是一种粒细胞集落刺激因子 (G-CSF)。Eflapegrastim 靶向 G-CSF 受体 (c-Fms)。Eflapegrastim 刺激中性粒细胞祖细胞的增殖和分化,维持成熟和功能性中性粒细胞数目稳定。Eflapegrastim 还缩短中性粒细胞减少的持续时间。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Eflapegrastim Chemical Structure

Eflapegrastim Chemical Structure

CAS No. : 1384099-30-2

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内


3.  试用装只面向终端客户

规格 是否有货
1 mg   询价  
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献


Eflapegrastim is a humanized IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia[1].

(In Vitro)

Eflapegrastim has an IgG4 Fc fragment and short polyethylene glycol linker[1].
Eflapegrastim (5.5-88 mM; 4 min) binds to FcRn but not Fcγ receptors or C1q[1].
Eflapegrastim (0.000036-0.709 nmol/L; 54 h) induces bone marrow cell proliferation[1].
Eflapegrastim (10 μM; 1 h) binds FcRn and undergoes FcRn-mediated transcytosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(In Vivo)

Eflapegrastim (100 μg/kg; s.c.; single dose) decreases the duration of neutropenia (DN) and increases levels of G-CSF in serum and marrow in chemotherapy-induced neutropenic rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6NCrl mice (4-6 weeks old)[1]
Dosage: (1) 9, 26, 53, and 88 µg/kg; (2) 62 µg/kg
Administration: Subcutaneous injection; single dose
Result: Reduced chemotherapy-induced neutropenia.
Clinical Trial

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

Eflapegrastim 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.


Your information is safe with us. * Required Fields.



* 需求量:

* 客户姓名:


* Email:

* 电话:


* 公司或机构名称:


Bulk Inquiry

Inquiry Information