2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease Apoptosis
  3. EGFR Dihydrofolate reductase (DHFR) Apoptosis
  4. EGFR/HER2/DHFR-IN-3

EGFR/HER2/DHFR-IN-3 (compound 4c) 是一种有效的 EGFR/HER2 双重抑制剂，IC50 值分别为 0.138 和 0.092 μM。EGFR/HER2/DHFR-IN-3 还抑制 DHFR，IC50 值为 0.193 M。EGFR/HER2/DHFR-IN-3 导致 MCF7 乳腺癌细胞周期停滞在 S 期，并诱导凋亡。

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EGFR/HER2/DHFR-IN-3 Chemical Structure

EGFR/HER2/DHFR-IN-3 Chemical Structure

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EGFR/HER2/DHFR-IN-3 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR/HER2/DHFR-IN-3 (compound 4c) is a potent dual inhibitor of EGFR/HER2, with IC50s of 0.138 and 0.092 μM, respectively. EGFR/HER2/DHFR-IN-3 also inhibits DHFR, with an IC50 of 0.193 M. EGFR/HER2/DHFR-IN-3 causes arrest at the S phase of the cell cycle and induces apoptosis in MCF7 breast cancer cells[1].

IC50 & Target[1]

EGFR

0.138 μM (IC50)

HER2

0.092 μM (IC50)

DHFR

0.193 μM (IC50)

分子量

373.40

Formula

C22H19N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR/HER2/DHFR-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2/DHFR-IN-3EGFRDihydrofolate reductase (DHFR)ApoptosisEpidermal growth factor receptorErbB-1HER1S phasecell cyclebreast cancerInhibitorinhibitorinhibit

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