1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  2. EGFR Thymidylate Synthase Apoptosis
  3. EGFR/HER2/TS-IN-1

EGFR/HER2/TS-IN-1 (Compound 4d) 是一种 EGFRHER2TS (Thymidylate synthase) 抑制剂,对 EGFR、HER2 和 TS 的IC50分别为 0.203、0.088 和 0.168 μM。EGFR/HER2/TS-IN-1 诱导 MCF7 细胞凋亡(apoptosis)。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

EGFR/HER2/TS-IN-1 Chemical Structure

EGFR/HER2/TS-IN-1 Chemical Structure

CAS No. : 2444363-11-3

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and TS (Thymidylate synthase) inhibitor with IC50 values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis[1].

IC50 & Target

EGFR

0.203 μM (IC50)

HER2

0.088 μM (IC50)

Thymidylate synthase

0.168 μM (IC50)

体外研究
(In Vitro)

EGFR/HER2/TS-IN-1 (Compound 4d) shows cytotoxicity with an IC50 of 0.693 μM against MCF7 cells[1].
EGFR/HER2/TS-IN-1 (10 μg, 24 h) arrests cell cycle at G2/M phase and induces cell apoptosis in MCF7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MCF7
Concentration: 10 μg
Incubation Time: 24 h
Result: Arrested cell cycle at G2/M phase.

Apoptosis Analysis[1]

Cell Line: MCF7
Concentration: 10 μg
Incubation Time: 24 h
Result: Induced cell apoptosis.
分子量

501.54

Formula

C24H15N5O4S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
EGFR/HER2/TS-IN-1
目录号:
HY-146238
需求量: