1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  2. EGFR Apoptosis
  3. EGFR-IN-56

EGFR-IN-56 (Compound 13a) 是一种有效的 EGFR 抑制剂,对EGFRT790MEGFRT790M/L858RIC50 值分别为 541.7 nM 和 132.1 nM。EGFR-IN-56 在 G2/M 期阻滞癌细胞,诱导细胞凋亡 (apoptosis)。

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EGFR-IN-56 Chemical Structure

EGFR-IN-56 Chemical Structure

CAS No. : 2477726-83-1

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  • 生物活性

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生物活性

EGFR-IN-56 (Compound 13a) is a potent EGFR inhibitor with IC50 values of 541.7 nM and 132.1 nM against EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-56 blocks cancer cells in G2/M phase and induce into late apoptosis[1].

IC50 & Target

EGFRT790M

541.7 nM (IC50)

EGFRL858R/T790M

132.1 nM (IC50)

分子量

434.51

Formula

C23H22N4O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
EGFR-IN-56
目录号:
HY-146136
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