Elemicin-d₃  (Synonyms: 榄香素-d₃)

Elemicin-d₃ is deuterated labeled Pemafibrate (HY-17618). Pemafibrate is a highly selective PPARα agonist, with an EC₅₀ of 1 nM.

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。
Elemicin (62.5、125、250、500、1000 μM) 在 HepG2 细胞中的 IC₅₀ 值为 910 μM^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Elemicin (500 mg/kg；口服灌胃；每 24 小时一次，持续 3 周) 会损害小鼠的肝功能。Elemicin 抑制肝脏 SCD1，导致溶血磷脂酰胆碱 (LPC) 失衡^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

211.27

C₁₂H₁₃D₃O₃

榄香素-d₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Yi-Kun Wang, et al. Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity. J Agric Food Chem. 2019 Jul 24;67(29):8243-8252.  [Content Brief]

  [3]. Yang XN, et al. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. Chem Res Toxicol. 2019 Sep 10.  [Content Brief]

  [4]. Xiao-Nan Yang, et al. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. Chem Res Toxicol. 2019 Oct 21;32(10):1965-1976.  [Content Brief]

  [5]. Ayodeji Oluwabunmi Oriola, et al. Essential Oils and Their Compounds as Potential Anti-Influenza Agents. Molecules. 2022 Nov 12;27(22):7797.  [Content Brief]