2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Fabesetron

Fabesetron  (Synonyms: FK1052 free base)

目录号: HY-105201
COA 产品使用指南

摩尔计算器

Fabesetron (FK1052) 是具有口服活性的 5-HT3 和 5-HT4 受体的拮抗剂。Fabesetron (FK1052) 可用于癌症化疗引起的急性和迟发性呕吐的研究。

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Fabesetron Chemical Structure

Fabesetron Chemical Structure

CAS No. : 129300-27-2

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Fabesetron 相关抗体

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fabesetron (FK1052) is an orally active 5-HT3 receptor antagonist with 5-HT4 receptor antagonistic activity. Fabesetron (FK1052) can be used in the study for both acute and delayed emesis induced by cancer chemotherapy[1][2].

IC50 & Target[1]

5-HT3 Receptor

 

5-HT4 Receptor

 

体内研究
(In Vivo)

Fabesetron (FK1052) (0.1 mg/kg p.o.) inhibits completely the increases in the colonic transit[1].
FK1052 (100 µg/kg) completely prevents emesis induced by cisplatin (18 mg/kg, i.p.) in Suncus murinus[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats weighing 220 to 330 g and male ddy mice weighing 25 to 35 g were used[1].
Dosage: 0.1 mg/kg.
Administration: P.O.
Result: Significantly caused delay and its degree of inhibition was 33.8 ± 4.8% by 0.1 mg/kg p.o..
Animal Model: Suncus murinus of either sex (>10-week-old; 30-70 g body weight)[2].
Dosage: 1, 10, and 100 µg/kg.
Administration: Orally administered 30 min before the injection of cisplatin.
Result: Inhibited cisplatininduced emesis in a dose-dependent manner, and no emesis was observed in three animals given the compound at 100 µg/kg.
分子量

293.36

Formula

C18H19N3O
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

法贝司琼
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Fabesetron 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fabesetron129300-27-2FK1052法贝司琼FK 1052FK-10525-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorcancerchemotherapyemesisInhibitorinhibitorinhibit

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