2. Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. TRP Channel Endogenous Metabolite
  4. Farnesyl pyrophosphate

Farnesyl pyrophosphate  (Synonyms: Farnesyl diphosphate)

目录号: HY-113037
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摩尔计算器

Farnesyl pyrophosphate (Farnesyl diphosphate) 是一种 15 碳类异戊二烯，是甲羟戊酸 (MVA) 途径的代谢中间体。Farnesyl pyrophosphate 是一种 TRPM2 (TRP Channel) 激动剂，可激活 TRPM2 打开，使离子流入到细胞内。Farnesyl pyrophosphate 是胆固醇合成、泛醌合成、蛋白质法尼基化修饰和香叶基-香叶基焦磷酸 (GGPP) 合成的关键分支底物。

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Farnesyl pyrophosphate Chemical Structure

Farnesyl pyrophosphate Chemical Structure

CAS No. : 13058-04-3

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Farnesyl pyrophosphate 的其他形式现货产品:

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Farnesyl pyrophosphate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Farnesyl pyrophosphate (Farnesyl diphosphate), a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis[1].

体外研究
(In Vitro)

Farnesyl pyrophosphate 作为一种确定的危险信号，可触发急性细胞死亡，导致中风中的神经元丢失。Farnesyl pyrophosphate 含有疏水性 15 碳异戊二烯基链和带大量电荷的焦磷酸头部，导致急性细胞死亡，与其下游代谢途径无关。从机制上讲，细胞外钙流入和阳离子通道瞬时受体电位 melastatin 2 (TRPM2) 在 Farnesyl pyrophosphate 诱导的细胞死亡中发挥重要作用。Farnesyl pyrophosphate 酸激活 TRPM2 开放离子流入[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Farnesyl pyrophosphate 相关抗体:
体内研究
(In Vivo)

就大脑中动脉闭塞（MCAO）构建的小鼠模型而言，Farnesyl pyrophosphate 在脑内蓄积，表明 Farnesyl pyrophosphate 和TRPM2危险信号轴在缺血性损伤中的作用。Farnesyl pyrophosphate/TRPM2 信号轴和 MVA 通路在脑缺血和潜在的神经退行性疾病中发挥重要作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

382.33

Formula

C15H28O7P2
CAS 号
中文名称

法尼基焦磷酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Farnesyl pyrophosphate 相关分类

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Keywords:

Farnesyl pyrophosphate13058-04-3Farnesyl diphosphate法尼基焦磷酸TRP ChannelEndogenous MetaboliteTransient receptor potential channelsTRPM2 agonist15-carbon isoprenoidmevalonate pathwaycell deathneurodegenerative diseasesInhibitorinhibitorinhibit

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