2. Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. TRP Channel Endogenous Metabolite Calcium Channel
  4. Farnesyl pyrophosphate

Farnesyl pyrophosphate  (Synonyms: Farnesyl diphosphate)

目录号: HY-113037B
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Farnesyl pyrophosphate 是甲羟戊酸 (MVA) 途径的代谢中间体。Farnesyl pyrophosphate 是一种 TRP Channel (TRPM2) 激动剂，可引发 Ca²⁺ 内流从而引发细胞死亡。Farnesyl pyrophosphate 是胆固醇合成、泛醌合成、蛋白质法尼基化修饰和香叶基-香叶基焦磷酸 (GGPP) 合成的关键分支底物。Farnesyl pyrophosphate 可用于脑缺血、神经退行性疾病、胰腺癌、炎症与自身免疫病等研究。

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Farnesyl pyrophosphate

Farnesyl pyrophosphate Chemical Structure

CAS No. : 372-97-4

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Farnesyl pyrophosphate 的其他形式现货产品:

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Farnesyl pyrophosphate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Farnesyl pyrophosphate is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.

体外研究
(In Vitro)

Farnesyl pyrophosphate (0-120 μg/mL，0-60 分钟) 可诱导 P815 细胞、A20 细胞、Jurkat T 细胞、脾细胞、胸腺细胞和神经元细胞死亡[1]。
Farnesyl pyrophosphate (0-60 μM，0-60 分钟) 可激活 P815 细胞中 TRPM2 的开放，促进 Ca2+ 内流[1]。
Farnesyl pyrophosphate (10 μM，14-26 小时) 可显著逆转 Simvastatin (HY-17502) 对 CT26 细胞引起的细胞毒性、ROS 升高和 AKT 磷酸化[2]。
Farnesyl pyrophosphate (10 μM，48 小时）显著逆转了 Simvastatin 对小鼠肠上皮内淋巴细胞 (IEL) 产生细胞因子的抑制作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Farnesyl pyrophosphate 相关抗体:
体内研究
(In Vivo)

Farnesyl pyrophosphate (30 mg/mL (3 μL)，注射至左侧纹状体，单剂量) 聚集在缺血性脑部区域，并在小鼠脑缺血和再灌注中诱导急性神经元死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Middle cerebral artery occlusion (MCAO) model established in adult C57BL/6J mice (male, 10 to 12 weeks old, weight: 22 to 26 g)[1]
Dosage: 30 mg/mL, 3 μL
Administration: Injected into the left striatum, single dose
Result: Induced acute neuron death.
Induced TRPM2-mediated cell death axis.
分子量

382.33

Formula

C15H28O7P2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Farnesyl pyrophosphate 相关分类

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Keywords:

Farnesyl pyrophosphate372-97-4Farnesyl diphosphateTRP ChannelEndogenous MetaboliteCalcium ChannelTransient receptor potential channelsCa2+ channelsCa channelsGGPP synthesision influxMVA pathwayInhibitorinhibitorinhibit

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