1. Membrane Transporter/Ion Channel
  2. P-glycoprotein
    BCRP
  3. FD 12-9

FD 12-9 (Synonyms: Ac12Az9)

目录号: HY-128685
产品使用指南

FD 12-9 是一种类黄酮二聚体,为 P-gpBCRP 的双重抑制剂,EC50 值分别为 285 nM 和 0.9 nM。具有抗胶质细胞瘤活性。

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FD 12-9 Chemical Structure

FD 12-9 Chemical Structure

CAS No. : 1451741-22-2

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Description

FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity[1].

IC50 & Target

EC50: 0.9 nM (BCRP), 285 nM (P-gp)[1]

Molecular Weight

877.93

Formula

C₅₁H₄₇N₃O₁₁

CAS No.

1451741-22-2

SMILES

O=C(OC)C1=CC=CC(COC2=C(C3=CC=C(OCCOCCOCCN4N=NC(CCCCOC5=CC=C6C(C=C(C7=CC=CC=C7)OC6=C5)=O)=C4)C=C3)OC8=CC=CC=C8C2=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
FD 12-9
目录号:
HY-128685
需求量: