1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. Fenoldopam

Fenoldopam  (Synonyms: 非诺多泮; SKF 82526)

目录号: HY-B0735
产品使用指南

Fenoldopam(SKF 82526)是D1受体部分激动剂。

该游离形式化合物不稳定,推荐具有相同生物学活性的稳定盐形式 Fenoldopam mesylate

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Fenoldopam Chemical Structure

Fenoldopam Chemical Structure

CAS No. : 67227-56-9

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Fenoldopam 的其他形式现货产品:

Other Forms of Fenoldopam:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fenoldopam(SKF 82526) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist. Target: D1 Receptor Fenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam stimulated cAMP accumulation in LLC-PK1 cells in a dose-dependent manner, an effect which could be blocked by the DA1-selective antagonist Sch 23390. Although fenoldopam was more potent than DA (EC50 55.5 +/- 7.75 nM vs. 1.65 +/- 0.64 microM) in stimulating cAMP accumulation in LLC-PK1 cells, the maximum stimulation obtained by fenoldopam was only 37% of the maximum stimulation obtained by DA(Emax 13.0 +/- 2.95 pmol/mg of protein vs. 35.6 +/- 10.19 pmol/mg of protein) [1]. Fenoldopam is a selective dopamine1 (DA1) receptor agonist. Most of the DA1 receptor agonist activity of fenoldopam resides in the R-enantiomer, which also shows weaker alpha 2-adrenoceptor antagonist activity Fenoldopam produces vasodilation in vascular beds that are rich in vascular DA1 receptors [2].

Clinical Trial
分子量

305.76

Formula

C16H16ClNO3

CAS 号
中文名称

非诺多泮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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