1. GPCR/G Protein Neuronal Signaling Apoptosis
  2. Dopamine Receptor Apoptosis
  3. Fenoldopam mesylate

Fenoldopam mesylate  (Synonyms: 非诺多泮甲磺酸盐; Fenoldopam methanesulfonate; SKF-82526 mesylate)

目录号: HY-B0735A 纯度: 99.94%
COA 产品使用指南

Fenoldopam mesylate (SKF-82526) 是一种 D1 receptor 激动剂和新型的 lysine-specific demethylase 1 (LSD1) 抑制剂 (IC50=0.8974 μM)。Fenoldopam mesylate 具有抗高血压和抗癌细胞增殖的活性,并能诱导细胞凋亡。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Fenoldopam mesylate Chemical Structure

Fenoldopam mesylate Chemical Structure

CAS No. : 67227-57-0

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥605
In-stock
5 mg ¥343
In-stock
10 mg ¥544
In-stock
50 mg ¥1800
In-stock
100 mg ¥2800
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Fenoldopam mesylate:

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].

IC50 & Target

IC50: 0.8974 μM (LSD1)[2]

体外研究
(In Vitro)

Fenoldopam is a partial agonist with low efficacy at DA1 receptors linked to cAMP generation in the LLC-PK1 cells[1].
Fenoldopam (0-300 μM; 48 or 72 h) displays significant antiproliferative activity against RCC cell lines[2].
Fenoldopam (5 μM and 10 μM; 72 h) induces cell apoptosis in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: 786-O, ACHN, and HK-2 cells
Concentration: 0-300 μM
Incubation Time: 48 or 72 hours
Result: Inhibited the growth of ACHN cells (IC50=16.55 μM, 48 h; IC50=10.34 μM, 72 h), 786-O cells (IC50=57.89 μM, 48 h; IC50=47.52 μM, 72 h), and HK2 cells (IC50>300 μM, 48h and 72 h).

Apoptosis Analysis[1]

Cell Line: ACHN cells
Concentration: 5 μM and 10 μM
Incubation Time: 72 hours
Result: Increased apoptotic cells from at 2.2% (control) to 47.7% (5 μM, fenoldopam) and 60.8% (10 μM, fenoldopam), respectively.
体内研究
(In Vivo)

Fenoldopam mesylate (subcutaneous injection; 100 mg/kg; once daily; 2 d) can induce arteritis in rats detected by magnetic resonance imaging (MRI)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley rats[3]
Dosage: 100 mg/kg
Administration: Subcutaneous injection; 100 mg/kg; once daily; 2 days
Result: Showed low-intensity areas and a high signal intensity region around the artery, and these findings were considered to be erythrocytes infiltrating the arterial wall and perivascular edema, respectively.
Observed perivascular edema histopathologically.
Clinical Trial
分子量

401.86

Formula

C17H20ClNO6S

CAS 号
性状

固体

颜色

White to off-white

中文名称

非诺多泮甲磺酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 36 mg/mL (89.58 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

H2O 中的溶解度 : 10 mg/mL (24.88 mM; 超声助溶)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4884 mL 12.4421 mL 24.8843 mL
5 mM 0.4977 mL 2.4884 mL 4.9769 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.94%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.4884 mL 12.4421 mL 24.8843 mL 62.2107 mL
5 mM 0.4977 mL 2.4884 mL 4.9769 mL 12.4421 mL
10 mM 0.2488 mL 1.2442 mL 2.4884 mL 6.2211 mL
15 mM 0.1659 mL 0.8295 mL 1.6590 mL 4.1474 mL
20 mM 0.1244 mL 0.6221 mL 1.2442 mL 3.1105 mL
DMSO 25 mM 0.0995 mL 0.4977 mL 0.9954 mL 2.4884 mL
30 mM 0.0829 mL 0.4147 mL 0.8295 mL 2.0737 mL
40 mM 0.0622 mL 0.3111 mL 0.6221 mL 1.5553 mL
50 mM 0.0498 mL 0.2488 mL 0.4977 mL 1.2442 mL
60 mM 0.0415 mL 0.2074 mL 0.4147 mL 1.0368 mL
80 mM 0.0311 mL 0.1555 mL 0.3111 mL 0.7776 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Fenoldopam mesylate
目录号:
HY-B0735A
需求量: