2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)
  4. Ferroptosis inducer-11

Ferroptosis inducer-11 是一种铁死亡 ferroptosis 诱导剂。Ferroptosis inducer-11 对 HCT-116、NCM-60 和 HT-29 细胞表现出显著的细胞毒性，其 IC50 值分别为 0.43 μM、3.14 μM 和 0.48 μM。Ferroptosis inducer-11 可强效抑制 GPX4 酶活性，其 IC50 为 1.86 μM。Ferroptosis inducer-11 能诱导铁死亡 ferroptosis ，并增加结肠癌细胞内脂质ROS、丙二醛 (MDA) 和 Fe2+ 水平，同时降低谷胱甘肽 (GSH) 水平。Ferroptosis inducer-11 可用于结肠癌的研究。

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Ferroptosis inducer-11

Ferroptosis inducer-11 Chemical Structure

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Ferroptosis inducer-11 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ferroptosis inducer-11 is a ferroptosis inducer. Ferroptosis inducer-11 exhibits potent cytotoxicity against HCT-116, NCM-60 and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM and 0.48 μM, respectively. Ferroptosis inducer-11 strongly suppresses GPX4 enzymatic activity with an IC50 of 1.86 μM. Ferroptosis inducer-11 induces ferroptosis, as well as increases intracellular lipid ROS, malondialdehyde (MDA), and Fe2+ levels, while decreasing glutathione (GSH) levels in colon cancer cells. Ferroptosis inducer-11 can be used for the study of colon cancer[1].

IC50 & Target[1]

GPX4

1.86 μM (IC50)

体外研究
(In Vitro)

Ferroptosis inducer-11 (Compound 30) (0.25-1 μM, 24 h) 对 HCT-116 结肠癌细胞的克隆形成表现出显著的抑制活性[1]。
Ferroptosis inducer-11 对 HCT-116、NCM-60 和 HT-29 细胞表现出强效的细胞毒性，其 IC50 值分别为 0.43 μM、3.14 μM 和 0.48 μM[1]。
Ferroptosis inducer-11 (0.25-1 μM, 6-24 h) 在 HCT-116 细胞中以时间和剂量依赖性方式显著升高脂质 ROS 水平[1]。
Ferroptosis inducer-11 (0.25-1 μM, 12 h) 在 HCT-116 细胞中剂量依赖性地升高 MDA 水平，增加细胞内 Fe2+ 水平并降低 GSH 水平[1]。
Ferroptosis inducer-11 对 GPX4 表现出强效的抑制活性，其 IC50 值为 1.86 μM[1]。
Ferroptosis inducer-11 (0.25-1 μM, 6-24 h) 在 HCT-116 细胞中以时间和剂量依赖性方式下调 GPX4 蛋白表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis inducer-11 相关抗体:

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.25, 0.5. 1 μM
Incubation Time: 6, 12, 24 h
Result: Downregulated GPX4 protein expression in a time- and dose-dependent manner in HCT-116 cells[1].
分子量

552.62

Formula

C30H36N2O8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ferroptosis inducer-11 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Ferroptosis inducer-11Ferroptosis inducer11Ferroptosis inducer 11FerroptosisGlutathione PeroxidaseReactive Oxygen Species (ROS)ferroptosisROSHCT-116 cellsNCM-60 cellsHT-29 cellsMDAGSHcolon cancerInhibitorinhibitorinhibit

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