2. Anti-infection
  3. Influenza Virus
  4. Firivumab

Firivumab  (Synonyms: CT-P22; CT120)

目录号: HY-P99620 纯度: 95.00%
COA

摩尔计算器

Firivumab (CT-P22; CT120) 是一种人 IgG1 单克隆甲型流感病毒血凝素 (Anti-IAV HA) 抗体。Firivumab 能够中和 H1N1、H5N1、H6N1、H6N2、H8N4、H8N8、H9N2 和 H12N7。Firivumab 在小鼠中显示出对 H1N1 病毒的保护作用。

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Firivumab Chemical Structure

Firivumab Chemical Structure

CAS No. : 1443004-15-6

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7500
In-stock
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50 mg   询价  

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Customer Review

Firivumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Firivumab (CT-P22; CT120) is a human IgG1 monoclonal influenza A virus hemagglutinin (Anti-IAV HA) antibody. Firivumab is capable of neutralizing H1N1, H5N1, H6N1, H6N2, H8N4, H8N8, H9N2 and H12N7. Firivumab shows protection against H1N1 virus in mice[1][2][3].

IC50 & Target

IC50: 0.1-1.3 μg/mL (H1N1), 0.78 μg/mL (H2N2), 0.48-0.65 μg/mL (H5N1), 4.69 μg/mL (H6N1), 4.69 μg/mL (H6N2), 2.34 μg/mL (H8N4), 1.3 μg/mL (H8N8), 2.08 μg/mL (H9N2) and 20.83 μg/mL (H12N7)[1]
体内研究
(In Vivo)

Firivumab (CT-P22; CT120; 7.5-30 mg/kg; 腹腔给药; 感染后 24 小时) 在 >15 mg/kg 处理组中对 H1N1 病毒显示 100% 的保护，在 7.5 mg/kg 处理组中显示 70% 的保护[1]。
Firivumab (添加 7.5 mg/kg Firivumab 和 7.5 mg/kg CT149) 在 A/California/04/09 (H1N1) 处理的小鼠中表现出全面保护[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six- to nine-week-old female BALB/c mice with A/California/04/09 (H1N1) and A/Philippines/2/1982 (H3N2)[1]
Dosage: 7.5, 15, 30 mg/kg
Administration: IP; Twenty-four hours post-infection
Result: Showed 100% protection against H1N1 virus in >15 mg/kg-treated group and 70% in 7.5 mg/kg-treated group.
Could not protect mice from H3N2 infection.
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Firivumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Firivumab1443004-15-6CT-P22 CT120CT120CT 120CT-120Influenza VirusHumanIgG1influenza A virushemagglutininAnti-IAV HAH1N1H2N2H5N1H6N1H6N2H8N4H8N8H9N2H12N7A/California/04/09A/Philippines/2/1982CT-P27CT149Inhibitorinhibitorinhibit

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