2. Protein Tyrosine Kinase/RTK
  3. Tie FLT3
  4. Flt-3 Inhibitor III

Flt-3 Inhibitor III 是一种有效的选择性 FLT3 kinase 激酶抑制剂，50 为 50 nM。Flt-3 Inhibitor III 对其他激酶的活性较低。Flt-3 Inhibitor III 具有抗癌作用。

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Flt-3 Inhibitor III Chemical Structure

Flt-3 Inhibitor III Chemical Structure

CAS No. : 852045-46-6

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Flt-3 Inhibitor III 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flt-3 Inhibitor III is a potent and selective FLT3 kinase inhibitor with an 50 of 50 nM. Flt-3 Inhibitor III shows less active against other kinases. Flt-3 Inhibitor III has anticancer effects[1].

IC50 & Target

Tie2

8.0 μM (IC50)

体外研究
(In Vitro)

Flt-3 Inhibitor III (compound 4) also inhibits c-Kit, KDR, c-Abl, CDK1, c-Src and Tie-2 with IC50 values of 0.26 µM, 0.91 µM, 1.2 µM, 2.1 µM, 2.8 µM, and 8.0 µM, respectively[1].
Flt-3 Inhibitor III (compound 4) blocks the proliferation of BaF3-ITD, BaF3-D835/Y, and MV4:11 cells, with IC50 values of 0.24 µM, 0.76 µM, and 0.052 µM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Flt-3 Inhibitor III 相关抗体:
分子量

365.49

Formula

C21H23N3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Flt-3 Inhibitor III 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flt-3 Inhibitor III852045-46-6TieFLT3Angiopoietin receptorCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3antileukemiaFLT3 kinaseanticancer effectInhibitorinhibitorinhibit

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