2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. FLT3-IN-22

FLT3-IN-22 (compound 22f) 是一种有效的 FLT3 抑制剂，对 FLT3 和 FLT3/D835Y 的 IC50 值分别为 0.941 nM 和 0.199 nM。FLT3-IN-22 对 MV4-11 细胞和表达突变 FLT 激酶的 Ba/F3 细胞系 (包括 FLT-D835Y 和 FLT3-F691L) 表现出强大的抗增殖活性。

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FLT3-IN-22

FLT3-IN-22 Chemical Structure

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FLT3-IN-22 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FLT3-IN-22 (compound 22f) is a potent FLT3 inhibitor with IC50 values of 0.941 nM and 0.199 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-22 exhibits strong antiproliferative activity against MV4-11 cells and the mutant FLT kinase expressed Ba/F3 cell lines, including FLT-D835Y and FLT3-F691L[1].

IC50 & Target

IC50: 0.941 nM (FLT3) and 0.199 nM (FLT3/D835Y)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BaF3 GI50
866 nM
Compound: 22f
Growth inhibition of mouse BaF3 cells measured after 72 hrs by alamar blue cell viability assay
Growth inhibition of mouse BaF3 cells measured after 72 hrs by alamar blue cell viability assay
[PMID: 37866334]
分子量

426.47

Formula

C24H22N6O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FLT3-IN-22 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLT3-IN-22FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3FLT3 inhibitorFLT3/D835YFLT3-F691Lanticancer effectInhibitorinhibitorinhibit

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产品名称：
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目录号：
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