1. Protein Tyrosine Kinase/RTK
  2. FLT3
  3. FLT3-IN-32 TFA

FLT3-IN-32 TFA 是一种强效的 FLT3 抑制剂,其针对 FLT3-ITD 和 FLT3-D835Y 的 IC50 值分别为 2.40 nM 和 3.83 nM。FLT3-IN-32 TFA 有效抑制人 MV4-11 细胞增殖/存活,其 IC50 值为 0.07 nM。FLT3-IN-32 TFA 可用于急性髓性白血病 (AML) 的研究。

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FLT3-IN-32 TFA

FLT3-IN-32 TFA Chemical Structure

CAS No. : 3047195-49-0

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Other Forms of FLT3-IN-32 TFA:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FLT3-IN-32 TFA is a potent FLT3 inhibitor with an IC50s of 2.40 nM and 3.83 nM against FLT3-ITD and FLT3-D835Y. FLT3-IN-32 TFA inhibits proliferation/survival of human MV4-11 cells with an IC50 of 0.07 nM. FLT3-IN-32 TFA can be used for the study of acute myeloid leukemia (AML)[1].

体外研究
(In Vitro)

FLT3-IN-32 TFA (Compound 29b) 对EOL-1 (IC50 = 0.02 nM)、MOLM-13 (IC50 = 0.20 nM)、MONO-MAC-1 (IC50 = 100 nM) 和 MONO-MAC-6 (IC50 = 0.65 nM) 具有抗增殖活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

629.58

Formula

C30H30F3N5O7

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
FLT3-IN-32 TFA
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HY-174437A
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