FM04 

FM04 is a potent P-glycoprotein (P-gp) inhibitor (EC₅₀=83 nM). FM04 inhibits P-gp in 2 mechanism: (1)FM04 binds to Q1193, followed by interacting with the functionally critical residues H1195 and T1226; or (2)FM04 binds to I1115 (a functionally critical residue itself), disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction and thereby inhibiting P-gp^[1].

FM04 抑制 P-糖蛋白的 EC₅₀=83 nM，这里的 EC₅₀ 值是指在 P-gp 过表达细胞系 LCC6MDR 中，紫杉醇 (PTX) 降低一半的有效调制剂浓度 IC₅₀ (=3.8 nM)^[1]。
FM04 (100 μM) 在 LCC6MDR 细胞中表现出与其光亲和衍生物 XC4 的竞争^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

415.48

C₂₆H₂₅NO₄

1807320-40-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu Z, et al. Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04. J Med Chem. 2023 Apr 25.  [Content Brief]