2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Fmoc-Lys(Pal-Glu-OtBu)-OH

Fmoc-Lys(Pal-Glu-OtBu)-OH 是可降解 (cleavable) 的 ADC linker，用于合成抗体偶联活性分子 (ADCs)。Fmoc-Lys(Pal-Glu-OtBu)-OH 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

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Fmoc-Lys(Pal-Glu-OtBu)-OH Chemical Structure

Fmoc-Lys(Pal-Glu-OtBu)-OH Chemical Structure

CAS No. : 1491158-62-3

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1 g ￥168
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Fmoc-Lys(Pal-Glu-OtBu)-OH 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys(Pal-Glu-OtBu)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target

Cleavable Linker

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-Lys(Pal-Glu-OtBu)-OH 相关抗体:
分子量

792.06

Formula

C46H69N3O8
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Fmoc-Lys(Pal-Glu-OtBu)-OH 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-Lys(Pal-Glu-OtBu)-OH1491158-62-3ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-W045822
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