2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection
  3. Calcium Channel Enterovirus
  4. Fukinolic acid

Fukinolic acid 是一种苄基酒石酸酯，是一种血管扩张剂，具有抗肠道病毒A71 (EV-A71) 复制的活性。Fukinolic acid 是一种受体调控的 Ca2+ 通道 (ROC) 抑制剂，它通过 Norepinephrine (HY-13715) 激活的 ROC 抑制细胞外 Ca2+ 内流，而不影响电压依赖性 Ca2+ 通道。

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Fukinolic acid

Fukinolic acid Chemical Structure

CAS No. : 50982-40-6

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Fukinolic acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a receptor-operated Ca2+ channels (ROC) inhibitor, suppressing extracellular Ca2+ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca2+ channels[1][2].

体外研究
(In Vitro)

Fukinolic acid (300 μM；1 小时；大鼠主动脉条) 可诱导 Norepinephrine 预收缩的大鼠主动脉条非内皮依赖性舒张，并通过抑制细胞外 Ca2+ 内流来抑制 Norepinephrine 孵育的大鼠主动脉条中 Ca2+ 诱导的收缩[1]。
Fukinolic acid (4.3 µg/mL；4 天) 可使 EV71 BrCr 病毒诱导的细胞病变效应降低 50%，并在 500 µg/mL 时引起 50% 的细胞毒性[2]。
Fukinolic acid (0-230 µM；16 小时；COS-1) 不抑制 EV-A71 3C 蛋白酶活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fukinolic acid 相关抗体:
分子量

434.35

Formula

C20H18O11
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fukinolic acid 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fukinolic acid50982-40-6Calcium ChannelEnterovirusCa2+ channelsCa channelsRhinovirusHRVHRVsHEVHEVsbenzyltartaric acid esterrat aortic stripsreceptor-operated Ca2+ channels (ROC)EV-A71antiviral activityInhibitorinhibitorinhibit

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