Gantenerumab  (Synonyms: 更汀芦单抗)

Gantenerumab is a fully humanized anti-Aβ IgG1 monoclonal antibody. Gantenerumab can specifically bind to Aβ fibrils and plaques and can be used in Alzheimer's disease research^[1].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

Amyloid Beta/Aβ

Gantenerumab (0.07-7 nM; 40-72 h) 在 AD 患者脑组织切片与原代人巨噬细胞或小胶质细胞共培养体系中，能浓度依赖性降低 Aβ 斑块负荷，EC₅₀ 约为 0.7 nM^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gantenerumab (20 mg/kg; 静脉注射; 每周 1 次; 5 个月) 在 PS2APP 转基因小鼠中具有保护作用，可减少 Aβ 淀粉样斑块数量^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

351  [NCBI]

P05067

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

146.28 kDa

1043556-46-2

液体

Colorless to light yellow

更汀芦单抗

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Human IgG1 kappa

• 
  Loaded Gantenerumab on AHC2 biosensor, can bind Amyloid Precursor/Beta-APP42 Protein, Human (His-GST, HY-P76168) with an affinity constant of 5.257E-11 M as determined in BLI assay.
• 
  Flow cytometric analysis of 1.5×10⁶ HUVEC cells with Gantenerumab (HY-P99022, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa, Isotype Control (HY-P99001, blue) was used as the isotype control.

• [1]. Bernd Bohrmann, et al. Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β. J Alzheimers Dis. 2012;28(1):49-69.  [Content Brief]