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  3. GATA4-NKX2-5-IN-1

GATA4-NKX2-5-IN-1 

目录号: HY-103484
产品使用指南

GATA4-NKX2-5-IN-1 (Compound 3) 剂量依赖性地抑制 GATA4–NKX2-5 转录协同作用,IC50 为 3 μM。 GATA4-NKX2-5-IN-1 对参与调节 GATA4 磷酸化的蛋白激酶没有活性。GATA4-NKX2-5-IN-1 调节肥大激动剂诱导的心脏基因表达。

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GATA4-NKX2-5-IN-1 Chemical Structure

GATA4-NKX2-5-IN-1 Chemical Structure

CAS No. : 544681-96-1

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Description

GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression[1].

IC50 & Target

IC50: 3 μM (GATA4–NKX2-5)[1]

Molecular Weight

349.43

Formula

C₂₁H₂₃N₃O₂

CAS No.

544681-96-1

SMILES

CC1=C(C(NC2=CC=C(N(CC)CC)C=C2)=O)C(C3=CC=CC=C3)=NO1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
GATA4-NKX2-5-IN-1
目录号:
HY-103484
需求量:

GATA4-NKX2-5-IN-1

Cat. No.: HY-103484