2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. GDC-0425

GDC-0425  (Synonyms: RG-7602)

目录号: HY-19926 纯度: 99.60%
COA 产品使用指南

摩尔计算器

GDC-0425 (RG-7602) 是一种有效的、具有口服活性的、高选择性的 ChK1 抑制剂。GDC-0425 可用于多种恶性肿瘤的研究。

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GDC-0425 Chemical Structure

GDC-0425 Chemical Structure

CAS No. : 1200129-48-1

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥700
In-stock
10 mg ￥1100
In-stock
25 mg ￥2200
In-stock
50 mg ￥3800
In-stock
100 mg ￥6000
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

GDC-0425 相关抗体

Top Publications Citing Use of Products

查看 Checkpoint Kinase (Chk) 亚型特异性产品:

查看所有亚型
Chk1 Chk2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GDC-0425 (RG-7602) is an orally available, highly selective small molecule ChK1 inhibitor. GDC-0425 can be used for the research of various malignancies[1][2].

IC50 & Target[1]

Chk1

 

体外研究
(In Vitro)

MEK inhibition either by pharmacologic inhibitors or RNAi-mediated gene silencing significantly protected cells from reduced viability upon GDC-0425 treatment[3].
GDC-0425 (3 μM; 24 hours) treatment results the hyperphosphorylation of Chk1[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GDC-0425 相关抗体:

Cell Viability Assay[3]

Cell Line: Chk1-positive breast cancer cell lines
Concentration: 0.001, 0.01, 0.1, 1, 10 mM
Incubation Time: 72 hours
Result: Reduced cell proliferation.

Cell Viability Assay[3]

Cell Line: U-2 OS cells
Concentration: 3 μM
Incubation Time: 24 hours
Result: Led to hyperphosphorylation of Chk1.
体内研究
(In Vivo)

GDC-0425 exhibits partial suppression of tumor growth. The Gemcitabine/GDC-0425 combination results in significant tumor regression in all tested models[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCr nude mice bearing xenografts of both osteosarcoma and triple-negative breast cancer models (143B PML BK TK, HCC1806, and HCC70 cell lines)[3]
Dosage: For the 4-arm study, mice were treated with vehicle, Gemcitabine 120 mg/kg, GDC-0425 75 mg/kg alone, or Gemcitabine and GDC-0425 combination for 15 days. For 6-arm studies of HCC1806 and HCC70 models, mice were treated with vehicle, Gemcitabine 120 mg/kg, GDC-0425 50 mg/kg, GDC-0425 75 mg/kg alone, or Gemcitabine and GDC-0425 combination.
Administration: Orally administrated at 24, 48, and 72 hours after gemcitabine administration by intraperitoneal injection.
Result: Exhibited partial suppression of tumor growth upon treatment with either Gemcitabine or GDC-0425 alone. Notably, the Gemcitabine/GDC-0425 combination resulted in significant tumor regression in all tested models.
Clinical Trial
分子量

321.38

Formula

C18H19N5O
CAS 号
性状

固体

颜色

Off-white to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O 中的溶解度 : 25 mg/mL (77.79 mM; 超声助溶; 酸性条件溶解 (HCL 调节，pH≈3))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1116 mL 15.5579 mL 31.1158 mL
5 mM 0.6223 mL 3.1116 mL 6.2232 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

GDC-0425 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.1116 mL 15.5579 mL 31.1158 mL 77.7895 mL
5 mM 0.6223 mL 3.1116 mL 6.2232 mL 15.5579 mL
10 mM 0.3112 mL 1.5558 mL 3.1116 mL 7.7790 mL
15 mM 0.2074 mL 1.0372 mL 2.0744 mL 5.1860 mL
20 mM 0.1556 mL 0.7779 mL 1.5558 mL 3.8895 mL
25 mM 0.1245 mL 0.6223 mL 1.2446 mL 3.1116 mL
30 mM 0.1037 mL 0.5186 mL 1.0372 mL 2.5930 mL
40 mM 0.0778 mL 0.3889 mL 0.7779 mL 1.9447 mL
50 mM 0.0622 mL 0.3112 mL 0.6223 mL 1.5558 mL
60 mM 0.0519 mL 0.2593 mL 0.5186 mL 1.2965 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GDC-04251200129-48-1RG-7602GDC0425GDC 0425RG7602RG 7602Checkpoint Kinase (Chk)checkpointkinaseChK1plasmaorallyavailablemalignanciesInhibitorinhibitorinhibit

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