2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Geissoschizoline

Geissoschizoline  (Synonyms: (+)-Geissoschizoline)

目录号: HY-N10429
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摩尔计算器

Geissoschizoline ((+)-Geissoschizoline) 是一种有效的人 AChE/BChE 抑制剂，其IC50s 分别为 20.40 µM 和 10.21 µM。Geissoschizoline 可用于预防神经变性和恢复神经传递方面的研究。Geissoschizoline 还具有抗炎作用。

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Geissoschizoline Chemical Structure

Geissoschizoline Chemical Structure

CAS No. : 18397-07-4

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Geissoschizoline 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Geissoschizoline ((+)-Geissoschizoline) is a potent inhibitor of human AChE/BChE, with IC50s of 20.40 µM and 10.21 µM, respectively. Geissoschizoline emerges as a possible multi-target prototype that can be very useful in studies of preventing neurodegeneration and restoring neurotransmission. Geissoschizoline aiso is a potent anti-inflammatory agent[1].

IC50 & Target

IC50: 20.40 µM (AChE), 10.21 µM (BChE)[1]
体外研究
(In Vitro)

Geissoschizoline(1 μM; 48 hours) significantly reduces production of TNF-α and NO in LPS-stimulated microglial cells [1].
Geissoschizoline(1, 10 and 30 μM; 24 hours) shows no cytotoxicity to LPS-stimulated microglial cells[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Geissoschizoline 相关抗体:

Cell Viability Assay[1]

Cell Line: LPS-stimulated microglial cells (pre-incubated with various concentrations (0.1- 10 μM) of geissoschizoline for 1 hour)
Concentration: 1 μM
Incubation Time: 48 hours
Result: Reduced neuroinflammation and increased neuroprotection, also restored synaptic transmission.

Cell Cytotoxicity Assay[1]

Cell Line: LPS-stimulated microglial cells
Concentration: 1, 10 and 30 μM
Incubation Time: 24 hours
Result: Did not affect cell viability.
分子量

298.42

Formula

C19H26N2O
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Geissoschizoline 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Geissoschizoline18397-07-4(+)-GeissoschizolineCholinesterase (ChE)neurodegenerationneurotransmissionanti-inflammatorymouse microglial N9 cellsInhibitorinhibitorinhibit

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