2. Gene
  3. Tyk2 - tyrosine kinase 2 Gene

Tyk2 - tyrosine kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：酪氨酸激酶 2

种属: Rattus norvegicus

基因 ID: 100361294 | 基因类型: protein coding

关于 Tyk2

Primary_assembly 8: 19,641,884-19,667,044 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 197 orthologues, 32 paralogues and is associated with 12 phenotypes. Biased expression in Spleen (RPKM 89.), Thymus (RPKM 65.1) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 1 型血管紧张素受体结合活性。预计参与细胞内信号转导和肽酰酪氨酸磷酸化。预测位于细胞质和细胞核中。该基因与免疫缺陷 35 相关的人类直系同源物。与人类 TYK2（酪氨酸激酶 2）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables type 1 Angiotensin Receptor binding activity. Predicted to be involved in intracellular signal transduction and peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human Tyk2 (tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tyk2 基因产物(1)

mRNA Protein Name
NM_001257347.1 NP_001244276.1 non-receptor tyrosine-protein kinase TYK2

Tyk2 蛋白结构

FERM_F1

FERM_F1: pfam18379 (32 - 129)

FERM_F2

FERM_F2: pfam18377 (147 - 270)

Jak1_Phl

Jak1_Phl: pfam17887 (289 - 432)

SH2

SH2: cl15255 (437 - 535)

PKc_like

PKc_like: cl21453 (590 - 865)

PTKc_Tyk2_rpt2

PTKc_Tyk2_rpt2: cd05080 (890 - 1172)

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  • 1186 a.a.
蛋白主名 其他名称

non-receptor tyrosine-protein kinase TYK2

相关产品

Approval
生物活性分子 (19)
目录号 产品名 作用方式
纯度 是否罕见病
HY-50856 Ruxolitinib Inhibitor 99.99% 是
HY-117287 Deucravacitinib Inhibitor 99.87% 是
HY-15315 Baricitinib Inhibitor 99.97% 是
HY-19569 Upadacitinib Inhibitor 99.98% 是
HY-50858 Ruxolitinib phosphate Inhibitor 99.98% 是
HY-16379 Pacritinib Inhibitor 99.93% 是
HY-18300 Filgotinib Inhibitor 99.68% 是
HY-107429 Abrocitinib Inhibitor 99.26% 否
HY-19568 Peficitinib Inhibitor 99.43% 是
HY-15315A Baricitinib phosphate Inhibitor 99.91% 是
HY-109053 Delgocitinib Inhibitor 99.87% 否
HY-13577A Oclacitinib maleate Inhibitor 99.63% 否
HY-13577 Oclacitinib Inhibitor 99.23% 否
HY-19568A Peficitinib hydrobromide Inhibitor / 否
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / 否
HY-18300A Filgotinib maleate Inhibitor / 否
HY-16379A Pacritinib hydrochloride Inhibitor / 否
HY-19568B Peficitinib hydrochloride Inhibitor / 否
HY-50859 Ruxolitinib sulfate Inhibitor / 否
Clinical Phase
生物活性分子 (11)
目录号 产品名 作用方式
纯度 Phase
HY-15999 Cerdulatinib Inhibitor 98.96% Phase 3
HY-12469 Decernotinib Inhibitor 99.67% Phase 3
HY-112724 Ivarmacitinib Inhibitor 99.82% Phase 3
HY-15999A Cerdulatinib hydrochloride Inhibitor 99.89% Phase 3
HY-13034 Gandotinib Inhibitor 99.82% Phase 2
HY-15270 BMS-911543 Inhibitor 98.53% Phase 2
HY-19631A Ilginatinib Inhibitor 99.94% Phase 2
HY-19631B Ilginatinib hydrochloride Inhibitor ≥98.0% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.87% Phase 2
HY-131968 BMS-986202 Inhibitor 99.92% Phase 1
HY-101024 PF-06263276 Inhibitor 99.38% Phase 1
Pre-clinical Phase
生物活性分子 (29)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-14435 Pyridone 6 Inhibitor 98.13% 否
HY-100895 SAR-20347 Inhibitor 97.12% 否
HY-14722 NVP-BSK805 Inhibitor 99.89% 否
HY-111745 Tyk2-IN-5 Inhibitor 98.87% 否
HY-101762 TyK2-IN-2 Inhibitor 98.64% 否
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% 否
HY-131906 JAK2-IN-7 Inhibitor 99.15% 否
HY-126242S Tyk2-IN-7 Inhibitor 99.62% 否
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 98.78% 否
HY-13961 GLPG0634 analog Inhibitor 98.58% 否
HY-111750 JAK-IN-3 Inhibitor 98.92% 否
HY-18710 BMS-066 Inhibitor / 否
HY-14722C NVP-BSK805 trihydrochloride Inhibitor / 否
HY-152080 TUL01101 Inhibitor / 否
HY-143885 JAK1/TYK2-IN-3 Inhibitor / 否
HY-149296 JAK1-IN-12 Inhibitor / 否
HY-153103 LRRK2/NUAK1/TYK2-IN-1 Inhibitor / 否
HY-143884 JAK2/TYK2-IN-1 Inhibitor / 否
HY-16640 TCJL37 Inhibitor / 否
HY-163304 Tyk2-IN-16 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-150720 TYK2-IN-12 Inhibitor / 否
HY-153440 JAK-IN-25 Inhibitor 98.44% 否
HY-157121 JAK-IN-34 Inhibitor / 否
HY-148060 JAK-IN-21 Inhibitor 99.72% 否
HY-154994 JAK-IN-30 Inhibitor / 否
HY-147754 JAK3/BTK-IN-6 Inhibitor / 否
HY-153058 LRRK2-IN-8 Inhibitor / 否
HY-18709 Tyk2-IN-3 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tyk2 NCBI NCBI:7297
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