1. Epigenetics
    Stem Cell/Wnt
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  2. JAK
  3. PF-06263276

PF-06263276 

目录号: HY-101024
产品使用指南

PF-06263276 (PF 6263276) 是一种有效、选择性的 pan-JAK 抑制剂,对 JAK1、JAK2、JAK3 和 TYK2 的抑制作用 IC50 值分别为 2.2 nM、23.1 nM、59.9 nM 和 29.7 nM。

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PF-06263276 Chemical Structure

PF-06263276 Chemical Structure

CAS No. : 1421502-62-6

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Description

PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively[1].

IC50 & Target[1]

JAK1

2.2 nM (IC50)

JAK2

23.1 nM (IC50)

JAK3

59.9 nM (IC50)

Tyk2

29.7 nM (IC50)

Clinical Trial
Molecular Weight

566.63

Formula

C₃₁H₃₁FN₈O₂

CAS No.

1421502-62-6

SMILES

FC1=C(O)C=C(CC)C(C2=CC(NN=C3C4=NC5=C(CN(C(C6=NC=C(N7CCCCC7)N=C6)=O)CC5)N4)=C3C=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
PF-06263276
目录号:
HY-101024
需求量:

PF-06263276

Cat. No.: HY-101024