CD226 - CD226 molecule Gene

中文名称：CD226 分子

种属: Homo sapiens

同用名: PTA1; DNAM1; DNAM-1; TLiSA1

基因 ID: 10666 | 基因类型: protein coding

关于 CD226

Cytogenetic location: 18q22.2 Genomic coordinates (GRCh38): 18:69,853,274-69,961,773 (from NCBI)

This gene has 8 transcripts (splice variants), 185 orthologues and 14 paralogues. Broad expression in spleen (RPKM 2.4), lymph node (RPKM 1.3) and 15 other tissues.

功能概要

该基因编码一种在 NK 细胞、血小板、单核细胞和 T 细胞亚群表面表达的糖蛋白。它是 Ig 超家族的成员，包含 2 个 Ig 样域的 V 集。该蛋白介导血小板和巨核细胞与血管内皮细胞的细胞粘附。该蛋白质还在巨核细胞成熟中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 1 月]

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

CD226 基因产物(3)

mRNA	Protein	Name
NM_001303618.2	NP_001290547.1	CD226 antigen isoform a precursor
NM_001303619.2	NP_001290548.1	CD226 antigen isoform b
NM_006566.4	NP_006557.2	CD226 antigen isoform a precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cell adhesion molecule binding	IPI IPI: 通过物理相互作用推断	12913096	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25465800	GOA
enables integrin binding	IPI IPI: 通过物理相互作用推断	16831868	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21982860	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	16831868	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of Fc receptor mediated stimulatory signaling pathway	IDA IDA: 通过直接分析推断	16831868	GOA
involved in positive regulation of T cell receptor signaling pathway	IMP IMP: 通过突变表型推断	26755705	GOA
involved in positive regulation of immunoglobulin mediated immune response	IDA IDA: 通过直接分析推断	16831868	GOA
involved in positive regulation of mast cell activation	IDA IDA: 通过直接分析推断	16831868	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IMP IMP: 通过突变表型推断	16304049	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IMP IMP: 通过突变表型推断	12913096	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	16831868	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD226 蛋白结构

V-set

Ig_2

0
100
200
300
336 a.a.

蛋白主名

其他名称

CD226 antigen

DNAX accessory molecule-1

CD226 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CD226	Q15762	PVR	Homo sapiens	P15151	SPR	30591568
种属内	CD226	Q15762	PVR	Homo sapiens	P15151	Protein Array	21982860
种属内	CD226	Q15762	ATP12A	Homo sapiens	P54707	Anti Tag CoIP	33961781
种属内	CD226	Q15762	EIF2B3	Homo sapiens	Q9NR50	Anti Tag CoIP	33961781
种属内	CD226	Q15762	BSCL2	Homo sapiens	Q96G97	Anti Tag CoIP	33961781
种属内	CD226	Q15762	ARL10	Homo sapiens	Q8N8L6	Anti Tag CoIP	33961781
种属内	CD226	Q15762	TIGIT	Homo sapiens	Q495A1	Anti Tag CoIP	25465800
种属内	CD226	Q15762	ATR	Homo sapiens	Q13535	Anti Tag CoIP	33961781
种属内	CD226	Q15762	EIF2B2	Homo sapiens	P49770	Anti Tag CoIP	33961781
种属内	CD226	Q15762	CD226	Homo sapiens	Q15762	FRET	25465800
种属内	CD226	Q15762	EIF2B4	Homo sapiens	Q9UI10	Anti Tag CoIP	33961781
种属内	CD226	Q15762	ATP2B3	Homo sapiens	Q16720	Anti Tag CoIP	33961781
种属内	CD226	Q15762	NECTIN2	Homo sapiens	Q92692	Protein Array	21982860
种属内	CD226	Q15762	EIF2B5	Homo sapiens	Q13144	Anti Tag CoIP	33961781
种属内	CD226	Q15762	CD226	Homo sapiens	Q15762	X-Ray Diffraction	30591568
种属内	CD226	Q15762	DSTYK	Homo sapiens	Q6XUX3	Anti Tag CoIP	33961781
种属内	CD226	Q15762	C4A	Homo sapiens	P0C0L4	Anti Tag CoIP	33961781
种属内	CD226	Q15762	TIGIT	Homo sapiens	Q495A1	FRET	25465800
种属内	CD226	Q15762	CDK5RAP3	Homo sapiens	Q96JB5	Anti Tag CoIP	33961781
种属内	CD226	Q15762	ATP13A1	Homo sapiens	Q9HD20	Anti Tag CoIP	33961781
种属内	CD226	Q15762	EIF2B1	Homo sapiens	Q14232	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD226 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70829	DNAM-1 Protein, Human (HEK293, Fc)	Q15762 (E19-N247)	≥95%
HY-P72668	DNAM-1 Protein, Human (HEK293, His)	Q15762 (E19-N247)	≥95%
HY-P78114	DNAM-1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q15762 (E19-N247)	≥95%
HY-P78429	DNAM-1 Protein, Human (HEK293, His-Avi)	Q15762 (E19-N247)	≥95%
HY-P78886	DNAM-1 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q15762 (E19-N247)	≥95%
HY-P700441	DNAM-1 Protein, Human (HEK293, hFc, Myc)	Q15762 (E19-N247)	≥95%

CD226 抗体

目录号	产品名	应用	反应物种
HY-P81691	CD226/DNAM1 Antibody (YA1436)	FC, ELISA	Human
HY-P82667	CD226/DNAM1 Antibody (YA2412)	WB	Human
HY-P84599	CD226/DNAM1 Antibody (YA4296)	IHC-P, FC, ELISA	Human

关联疾病

疾病名称

别名

Mature Teratoma Of The Ovary

Ovarian Cystic Teratoma

Nk Cell Deficiency

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02211	CD226 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS16914	Cd226 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23356	Cd226 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CD226	MGD	MGI:3039602
Bos taurus	CD226	VGNC	VGNC:27013
Macaca mulatta	CD226	VGNC	VGNC:101435
Rattus norvegicus	CD226	RGD	RGD:1311513
Canis familiaris	CD226	VGNC	VGNC:38940
Felis catus	CD226	VGNC	VGNC:60598
Macaca fascicularis	CD226	NCBI	NCBI:102117316
Others	CD226	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CD226 - CD226 molecule Gene

关于 CD226

功能概要

CD226 基因产物(3)

CD226 蛋白结构

CD226 蛋白互作信息

重组 CD226 蛋白

CD226 抗体

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

CD226 - CD226 molecule Gene

关于 CD226

功能概要

CD226 基因产物(3)

CD226 蛋白结构

CD226 蛋白互作信息

重组 CD226 蛋白

CD226 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z