2. Gene
  3. CD226 - CD226 molecule Gene

CD226 - CD226 molecule Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CD226 分子

种属: Homo sapiens

同用名: PTA1; DNAM1; DNAM-1; TLiSA1

基因 ID: 10666 | 基因类型: protein coding

关于 CD226

Cytogenetic location: 18q22.2 Genomic coordinates (GRCh38): 18:69,853,274-69,961,773 (from NCBI)

This gene has 8 transcripts (splice variants), 185 orthologues and 14 paralogues. Broad expression in spleen (RPKM 2.4), lymph node (RPKM 1.3) and 15 other tissues.

功能概要

该基因编码一种在 NK 细胞、血小板、单核细胞和 T 细胞亚群表面表达的糖蛋白。它是 Ig 超家族的成员，包含 2 个 Ig 样域的 V 集。该蛋白介导血小板和巨核细胞与血管内皮细胞的细胞粘附。该蛋白质还在巨核细胞成熟中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 1 月]

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

CD226 基因产物(3)

mRNA Protein Name
NM_001303618.2 NP_001290547.1 CD226 antigen isoform a precursor
NM_001303619.2 NP_001290548.1 CD226 antigen isoform b
NM_006566.4 NP_006557.2 CD226 antigen isoform a precursor

CD226 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (31 - 124)

Ig_2

Ig_2: Immunoglobulin domain (140 - 239)

  • 0
  • 100
  • 200
  • 300
  • 336 a.a.
蛋白主名 其他名称

CD226 antigen

DNAX accessory molecule-1

重组 CD226 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70829 DNAM-1 Protein, Human (HEK293, Fc) Q15762 (E19-N247) ≥95%
HY-P72668 DNAM-1 Protein, Human (229a.a, HEK293, His) Q15762 (E19-N247) ≥95%
HY-P72891 DNAM-1 Protein, Human (HEK293, His-Fc) Q15762 (M1-N247) ≥95%
HY-P73514 DNAM-1 Protein, Human (247a.a, HEK293, His) Q15762 (M1-N247) ≥95%
HY-P78114 DNAM-1 Protein, Human (Biotinylated, HEK293, His-Avi) Q15762 (E19-N247) ≥95%
HY-P78429 DNAM-1 Protein, Human (HEK293, His-Avi) Q15762 (E19-N247) ≥95%
HY-P78886 DNAM-1 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q15762 (E19-N247) ≥95%
HY-P700441 DNAM-1 Protein, Human (HEK293, hFc, Myc) Q15762 (E19-N247) ≥95%

关联疾病

疾病名称 别名
Mature Teratoma Of The Ovary
Ovarian Cystic Teratoma
Nk Cell Deficiency
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02211 CD226 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CD226 MGD MGI:3039602
Bos taurus CD226 VGNC VGNC:27013
Macaca mulatta CD226 VGNC VGNC:101435
Rattus norvegicus CD226 RGD RGD:1311513
Canis familiaris CD226 VGNC VGNC:38940
Felis catus CD226 VGNC VGNC:60598
Macaca fascicularis CD226 NCBI
Others CD226 NCBI
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