LILRB5 - leukocyte immunoglobulin like receptor B5 Gene

中文名称：白细胞免疫球蛋白样受体 B5

种属: Homo sapiens

同用名: LIR8; CD85C; LIR-8

关于 LILRB5

功能概要

该基因是白细胞免疫球蛋白样受体 (LIR) 家族的成员，该家族位于染色体区域 19q13.4 的基因簇中。编码的蛋白质属于 B 类 LIR 受体亚科，其中包含两个或四个细胞外免疫球蛋白结构域、一个跨膜结构域和两个至四个基于细胞质免疫受体酪氨酸的抑制基序 (ITIM) 。其他几种 LIR 亚家族 B 受体在免疫细胞上表达，它们与抗原呈递细胞上的 MHC I 类分子结合并抑制免疫反应的刺激。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]