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  2. LRRC3B - leucine rich repeat containing 3B Gene

LRRC3B - leucine rich repeat containing 3B Gene

中文名称:含富含亮氨酸重复序列 3B

种属: Homo sapiens

同用名: LRP15

基因 ID: 116135 | 基因类型: protein coding

关于 LRRC3B

Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38): 3:26,622,772-26,710,776 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues and 22 paralogues. Biased expression in brain (RPKM 1.4), testis (RPKM 0.6) and 3 other tissues.

功能概要

该基因编码的蛋白质是一种肿瘤抑制因子,在胃癌、肾癌、结直肠癌、肺癌和乳腺癌组织中表达水平较低。该基因的启动子在这些癌组织中经常被超甲基化,尽管超甲基化似乎并不是该基因表达减少的原因。已发现该基因的几种转录变体编码相同的蛋白质。[RefSeq 提供,2015 年 12 月]

The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast Cancer tissues. The promoter of this gene is frequently hypermethylated in these Cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

LRRC3B 基因产物(8)

mRNA Protein Name
NM_001317808.2 NP_001304737.1 leucine-rich repeat-containing protein 3B precursor
NM_001317809.2 NP_001304738.1 leucine-rich repeat-containing protein 3B precursor
NM_001317810.3 NP_001304739.1 leucine-rich repeat-containing protein 3B precursor
NM_001317811.2 NP_001304740.1 leucine-rich repeat-containing protein 3B precursor
NM_001395645.1 NP_001382574.1 leucine-rich repeat-containing protein 3B precursor
NM_001395646.1 NP_001382575.1 leucine-rich repeat-containing protein 3B precursor
NM_001395647.1 NP_001382576.1 leucine-rich repeat-containing protein 3B precursor
NM_052953.4 NP_443185.1 leucine-rich repeat-containing protein 3B precursor

LRRC3B 蛋白结构

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (33 - 63)

LRR_8

LRR_8: Leucine rich repeat (69 - 111)

LRR_1

LRR_1: Leucine Rich Repeat (115 - 136)

  • 0
  • 100
  • 200
  • 259 a.a.
蛋白主名 其他名称

leucine-rich repeat-containing protein 3B

leucine-rich repeat protein 15

重组 LRRC3B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70894 LRRC3B Protein, Human (HEK293, His) Q96PB8 (C34-Y204) ≥95%

直系同源

种属 基因名 来源 基因 ID
Bos taurus LRRC3B VGNC VGNC:52799
Rattus norvegicus LRRC3B RGD RGD:1311897
Mus musculus LRRC3B MGD MGI:2384996
Felis catus LRRC3B VGNC VGNC:63298
Macaca mulatta LRRC3B VGNC VGNC:110356
Canis familiaris LRRC3B VGNC VGNC:52891
Others LRRC3B NCBI